{"id":"azelastine-intranasal-application","safety":{"commonSideEffects":[{"rate":null,"effect":"Bitter taste"},{"rate":null,"effect":"Nasal irritation"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Somnolence"}]},"_chembl":{"chemblId":"CHEMBL1200809","moleculeType":"Small molecule","molecularWeight":"418.37"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Azelastine competitively antagonizes H1 histamine receptors on mast cells and other immune cells in nasal tissue, preventing histamine release and reducing allergic inflammation. When applied intranasally, it provides rapid local relief of allergic rhinitis symptoms including nasal congestion, sneezing, and rhinorrhea by suppressing the cascade of allergic mediators at the site of inflammation.","oneSentence":"Azelastine is a selective H1-receptor antagonist that blocks histamine-mediated allergic responses in the nasal mucosa.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:27:58.530Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Allergic rhinitis (seasonal and perennial)"},{"name":"Vasomotor rhinitis"}]},"trialDetails":[{"nctId":"NCT02557269","phase":"PHASE4","title":"4\"S\" - Seasonal Symptoms Suppression Study","status":"UNKNOWN","sponsor":"Association Asthma, Bulgaria","startDate":"2015-05","conditions":"Seasonal Allergic Rhinitis","enrollment":60}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Allergodil"],"phase":"marketed","status":"active","brandName":"Azelastine - intranasal application","genericName":"Azelastine - intranasal application","companyName":"Association Asthma, Bulgaria","companyId":"association-asthma-bulgaria","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Azelastine is a selective H1-receptor antagonist that blocks histamine-mediated allergic responses in the nasal mucosa. Used for Allergic rhinitis (seasonal and perennial), Vasomotor rhinitis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}