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The exact molecular targets are not fully characterized but involve multiple pathways affecting bacterial growth, inflammation, and pigmentation.","oneSentence":"Azelaic acid reduces bacterial colonization and normalizes keratinization to treat inflammatory skin conditions.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:28:01.904Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Rosacea"},{"name":"Acne vulgaris"},{"name":"Post-inflammatory hyperpigmentation"}]},"trialDetails":[{"nctId":"NCT07327983","phase":"NA","title":"Azelaic Acid 20% vs Hydroquinone 4% in Epidermal Melasma","status":"COMPLETED","sponsor":"Gujranwala medical college District Headquarters Hospital, Gujranwala","startDate":"2025-05-04","conditions":"Melasma, Melasma (Facial Melasma)","enrollment":146},{"nctId":"NCT05446402","phase":"PHASE4","title":"Investigation of the Tolerability of Two Facial Cleansing Routines for Mild to Moderate Acne","status":"COMPLETED","sponsor":"Northwestern University","startDate":"2022-06-15","conditions":"Acne","enrollment":29},{"nctId":"NCT05887219","phase":"PHASE1","title":"Comparison of Azelaic Acid 20 % Cream Versus Hydroquinone 4% Cream as an Adjuvant to Oral Tranexamic Acid in Melasma","status":"COMPLETED","sponsor":"Combined Military Hospital Abbottabad","startDate":"2022-11-01","conditions":"Melasma","enrollment":50},{"nctId":"NCT03826277","phase":"NA","title":"Efficacy of Melanostop Peeling for Improvement of Melasma","status":"UNKNOWN","sponsor":"VIST - Faculty of Applied Sciences","startDate":"2019-02-01","conditions":"Melasma","enrollment":10},{"nctId":"NCT01494467","phase":"PHASE3","title":"Phase 3 Papulopustular Rosacea Study","status":"COMPLETED","sponsor":"Galderma R&D","startDate":"2011-12","conditions":"Papulopustular Rosacea","enrollment":688},{"nctId":"NCT01493687","phase":"PHASE3","title":"Phase 3 Papulopustular Rosacea Study","status":"COMPLETED","sponsor":"Galderma R&D","startDate":"2011-12","conditions":"Papulopustular Rosacea (PPR)","enrollment":683},{"nctId":"NCT02602470","phase":"","title":"Preferences & Treatment Satisfaction Drivers in Rosacea Patients","status":"COMPLETED","sponsor":"LEO Pharma","startDate":"2015-01-08","conditions":"Rosacea","enrollment":206},{"nctId":"NCT02058628","phase":"PHASE4","title":"Comparison of the Efficacy and Safety of Clindamycin + Benzoyl Peroxide Formulation With Azelaic Acid Formulation in the Treatment of Acne Vulgaris","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2014-02-21","conditions":"Acne Vulgaris","enrollment":222},{"nctId":"NCT00848458","phase":"PHASE2, PHASE3","title":"Azelaic Acid Iontophoresis Versus Topical Azelaic Acid Cream in the Treatment of Melasma","status":"UNKNOWN","sponsor":"Medical University of Vienna","startDate":"2009-01","conditions":"Melasma","enrollment":70},{"nctId":"NCT00927771","phase":"PHASE4","title":"Azelaic Acid Versus Hydroquinone in Melasma","status":"UNKNOWN","sponsor":"Callender Center for Clinical Research","startDate":"2009-06","conditions":"Melanosis","enrollment":30}],"_emaApprovals":[],"_faersSignals":[{"count":1,"reaction":"ABDOMINAL PAIN LOWER"},{"count":1,"reaction":"APPLICATION SITE ERYTHEMA"},{"count":1,"reaction":"APPLICATION SITE HYPOAESTHESIA"},{"count":1,"reaction":"APPLICATION SITE SWELLING"},{"count":1,"reaction":"BLOOD PRESSURE SYSTOLIC INCREASED"},{"count":1,"reaction":"DEPRESSION"},{"count":1,"reaction":"DIPLOPIA"},{"count":1,"reaction":"DYSLIPIDAEMIA"},{"count":1,"reaction":"FLATULENCE"},{"count":1,"reaction":"HYPERTENSION"}],"_approvalHistory":[],"publicationCount":33,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Finacea Gel"],"phase":"marketed","status":"active","brandName":"Azelaic Acid Cream","genericName":"Azelaic Acid Cream","companyName":"LEO Pharma","companyId":"leo-pharma","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Azelaic acid reduces bacterial colonization and normalizes keratinization to treat inflammatory skin conditions. Used for Rosacea, Acne vulgaris, Post-inflammatory hyperpigmentation.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}