{"id":"azelaic-acid-15-gel","safety":{"commonSideEffects":[{"rate":null,"effect":"Pruritus"},{"rate":null,"effect":"Erythema"},{"rate":null,"effect":"Burning sensation"},{"rate":null,"effect":"Scaling"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Azelaic acid works through multiple mechanisms: it inhibits the growth of Cutibacterium acnes and Staphylococcus epidermidis, reduces the production of inflammatory mediators, and normalizes follicular keratinization. It also has tyrosinase-inhibiting properties that help reduce hyperpigmentation. These combined effects make it effective for treating acne and rosacea by addressing both bacterial and inflammatory components of the disease.","oneSentence":"Azelaic acid reduces bacterial colonization and normalizes keratinization while exerting anti-inflammatory and antimicrobial effects on the skin.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:40:28.337Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acne vulgaris"},{"name":"Rosacea"},{"name":"Post-inflammatory hyperpigmentation"}]},"trialDetails":[{"nctId":"NCT05446402","phase":"PHASE4","title":"Investigation of the Tolerability of Two Facial Cleansing Routines for Mild to Moderate Acne","status":"COMPLETED","sponsor":"Northwestern University","startDate":"2022-06-15","conditions":"Acne","enrollment":29},{"nctId":"NCT03094403","phase":"PHASE1","title":"To Evaluate the Therapeutic Equivalence and Safety of Azelaic Acid 15% Topical Gel","status":"COMPLETED","sponsor":"Sun Pharmaceutical Industries, Inc.","startDate":"2016-07-01","conditions":"Rosacea","enrollment":1000},{"nctId":"NCT00417937","phase":"PHASE4","title":"A Multicenter Trial of a Topical Medication for Papulopustular Rosacea Applied Twice Daily Versus Once Daily","status":"COMPLETED","sponsor":"LEO Pharma","startDate":"2007-01","conditions":"Papulopustular Rosacea","enrollment":98},{"nctId":"NCT00408330","phase":"PHASE2","title":"A Study of Azelaic Acid (AzA) 15% Gel in the Treatment of Seborrheic Dermatitis of the Face","status":"COMPLETED","sponsor":"LEO Pharma","startDate":"2006-12","conditions":"Seborrheic Dermatitis on the Face","enrollment":48},{"nctId":"NCT00403949","phase":"PHASE2","title":"A Study of Azelaic Acid (AzA) 15% in Topical Treatment of Mild to Moderate Perioral Dermatitis","status":"COMPLETED","sponsor":"LEO Pharma","startDate":"2006-11","conditions":"Perioral Dermatitis","enrollment":48},{"nctId":"NCT00031096","phase":"PHASE3","title":"Comparison of Efficacy and Safety of Azelaic Acid 15% Gel With Its Vehicle in Subjects With Mild to Moderate Acne","status":"COMPLETED","sponsor":"LEO Pharma","startDate":"2002-01","conditions":"Acne Vulgaris","enrollment":879},{"nctId":"NCT01257919","phase":"PHASE1","title":"Safety and Pharmacokinetics of Azelaic Acid Foam, 15% in Papulopustular Rosacea","status":"COMPLETED","sponsor":"LEO Pharma","startDate":"2011-01","conditions":"Papulopustular Rosacea","enrollment":21},{"nctId":"NCT01659853","phase":"PHASE3","title":"Efficacy and Safety Study Comparing CD07805/47 Gel 0.5% to Azelaic Acid Gel 15% in Subjects With Erythema of Rosacea","status":"COMPLETED","sponsor":"Galderma R&D","startDate":"2012-09","conditions":"Erythema, Rosacea","enrollment":70},{"nctId":"NCT01139008","phase":"PHASE4","title":"Split-Face Tolerability Comparison Between MetroGel® 1% Versus Finacea® 15% in Subjects With Healthy Skin","status":"COMPLETED","sponsor":"Galderma R&D","startDate":"2010-06","conditions":"Skin 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Rosacea","status":"COMPLETED","sponsor":"Wake Forest University","startDate":"2010-12","conditions":"Rosacea","enrollment":20},{"nctId":"NCT02147691","phase":"PHASE4","title":"Finacea 15% and Brimonidine 0.33% Gel in the Treatment of Rosacea - A Pilot Study","status":"COMPLETED","sponsor":"Derm Research, PLLC","startDate":"2014-05","conditions":"Acne Rosacea","enrollment":22},{"nctId":"NCT01387048","phase":"PHASE4","title":"Study for Long-term Treatment of Acne Vulgaris With Skinoren Versus Differin","status":"COMPLETED","sponsor":"University of Magdeburg","startDate":"2011-08","conditions":"Acne Vulgaris","enrollment":60},{"nctId":"NCT01038869","phase":"PHASE4","title":"Efficacy and Safety Study of Finacea to Treat Acne Vulgaris and Post-Inflammatory Hyperpigmentation (PIH)","status":"COMPLETED","sponsor":"Derm Research, PLLC","startDate":"2009-12","conditions":"Acne Vulgaris, Post Inflammatory Hyperpigmentation","enrollment":20},{"nctId":"NCT00848458","phase":"PHASE2, PHASE3","title":"Azelaic Acid Iontophoresis Versus Topical Azelaic Acid Cream in the Treatment of Melasma","status":"UNKNOWN","sponsor":"Medical University of Vienna","startDate":"2009-01","conditions":"Melasma","enrollment":70},{"nctId":"NCT00927771","phase":"PHASE4","title":"Azelaic Acid Versus Hydroquinone in Melasma","status":"UNKNOWN","sponsor":"Callender Center for Clinical Research","startDate":"2009-06","conditions":"Melanosis","enrollment":30}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":25,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Finacea® 15% Gel","Finacea","Finacea® gel 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Used for Acne vulgaris, Rosacea, Post-inflammatory hyperpigmentation.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}