{"id":"azd2927","safety":{"commonSideEffects":[{"rate":"null","effect":"Increased risk of infections"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"By inhibiting these enzymes, AZD2927 aims to modulate the immune response and potentially treat various diseases. The PI3K delta and PI3K gamma enzymes play a role in the activation of immune cells, and their inhibition may help to reduce inflammation and prevent autoimmune diseases.","oneSentence":"AZD2927 is a small molecule inhibitor of the PI3K delta and PI3K gamma enzymes.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T02:30:21.398Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Treatment of autoimmune diseases"}]},"trialDetails":[{"nctId":"NCT01396226","phase":"PHASE2","title":"A Multi-centre Study Comparing the Effects of AZD2927 and Placebo on the Electrical Activity in the Heart in Patients","status":"COMPLETED","sponsor":"AstraZeneca","startDate":"2011-09","conditions":"Arrhythmia","enrollment":20},{"nctId":"NCT01264250","phase":"PHASE1","title":"A Study to Assess the Safety, Tolerability and Pharmacokinetics After Single Ascending Intravenous Doses of AZD2927 in Healthy Male Volunteers","status":"COMPLETED","sponsor":"AstraZeneca","startDate":"2011-01","conditions":"Healthy","enrollment":48}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_2","status":"active","brandName":"AZD2927","genericName":"AZD2927","companyName":"AstraZeneca","companyId":"astrazeneca","modality":"Small molecule","firstApprovalDate":"","aiSummary":"AZD2927 is a small molecule inhibitor of the PI3K delta and PI3K gamma enzymes. Used for Treatment of autoimmune diseases.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}