{"id":"azd1419","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Conjunctival hemorrhage"},{"rate":"10-20%","effect":"Eye pain"},{"rate":"5-10%","effect":"Conjunctival hyperemia"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"AZD1419 works by binding to Ang-2, thereby inhibiting its interaction with its receptor Tie2, which plays a role in angiogenesis and inflammation. This mechanism of action is thought to contribute to its therapeutic effects in various diseases.","oneSentence":"AZD1419 is a recombinant human angiopoietin-2 (Ang-2) decoy receptor.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T02:30:16.416Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Geographic atrophy secondary to age-related macular degeneration"}]},"trialDetails":[{"nctId":"NCT02898662","phase":"PHASE2","title":"AZD1419 Ph2a Study","status":"COMPLETED","sponsor":"AstraZeneca","startDate":"2016-10-12","conditions":"Asthma","enrollment":81}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_2","status":"active","brandName":"AZD1419","genericName":"AZD1419","companyName":"AstraZeneca","companyId":"astrazeneca","modality":"Small molecule","firstApprovalDate":"","aiSummary":"AZD1419 is a recombinant human angiopoietin-2 (Ang-2) decoy receptor. Used for Geographic atrophy secondary to age-related macular degeneration.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}