{"id":"azd0585","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypoglycemia"},{"rate":null,"effect":"Gastrointestinal disorders"},{"rate":null,"effect":"Headache"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Glucokinase is a key glucose sensor in pancreatic beta cells that regulates insulin secretion in response to blood glucose levels. By activating glucokinase, AZD0585 increases the sensitivity of beta cells to glucose, promoting insulin secretion in a glucose-dependent manner. This mechanism aims to improve glycemic control while minimizing hypoglycemia risk since insulin secretion is tied to actual glucose levels.","oneSentence":"AZD0585 is a selective activator of the glucokinase enzyme that enhances glucose sensing and insulin secretion in pancreatic beta cells.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:42:20.223Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Type 2 diabetes mellitus"}]},"trialDetails":[{"nctId":"NCT02463071","phase":"PHASE3","title":"AZD0585 Phase III Long-term Study in Japan","status":"COMPLETED","sponsor":"AstraZeneca","startDate":"2015-06-10","conditions":"Hypertriglyceridemia","enrollment":383},{"nctId":"NCT02372344","phase":"PHASE1","title":"A Study to Investigate the Effect of Food on Pharmacokinetics of Total EPA and Total DHA of AZD0585 in Healthy Male Japanese Subjects","status":"COMPLETED","sponsor":"AstraZeneca","startDate":"2015-03","conditions":"Healthy","enrollment":72}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Epanova","Corn oil"],"phase":"phase_3","status":"active","brandName":"AZD0585","genericName":"AZD0585","companyName":"AstraZeneca","companyId":"astrazeneca","modality":"Small molecule","firstApprovalDate":"","aiSummary":"AZD0585 is a selective activator of the glucokinase enzyme that enhances glucose sensing and insulin secretion in pancreatic beta cells. Used for Type 2 diabetes mellitus.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}