{"id":"azathioprine-of-150-75-150-mg-per-day","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Nausea"},{"rate":"5-10%","effect":"Vomiting"},{"rate":"5-10%","effect":"Diarrhea"},{"rate":"5-10%","effect":"Leukopenia"},{"rate":"1-5%","effect":"Thrombocytopenia"}]},"_chembl":{"chemblId":"CHEMBL3663453","moleculeType":"Small molecule","molecularWeight":"444.47"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"This mechanism of action is achieved through the inhibition of the enzyme inosine monophosphate dehydrogenase, which is necessary for the synthesis of guanine nucleotides. As a result, azathioprine suppresses the immune system, making it useful for preventing organ rejection in transplant patients and treating autoimmune diseases.","oneSentence":"Azathioprine is an immunosuppressive medication that works by inhibiting the synthesis of purine nucleotides, thereby suppressing the proliferation of T and B lymphocytes.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:03:11.717Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of organ rejection in transplant patients"},{"name":"Treatment of autoimmune diseases such as rheumatoid arthritis and lupus"}]},"trialDetails":[],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"azathioprine of 150 [75; 150] mg per day","genericName":"azathioprine of 150 [75; 150] mg per day","companyName":"I.M. Sechenov First Moscow State Medical University","companyId":"i-m-sechenov-first-moscow-state-medical-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Azathioprine is an immunosuppressive medication that works by inhibiting the synthesis of purine nucleotides, thereby suppressing the proliferation of T and B lymphocytes. Used for Prevention of organ rejection in transplant patients, Treatment of autoimmune diseases such as rheumatoid arthritis and lupus.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":false,"score":3}}