{"id":"azathioprine-6-mercaptopurine","safety":{"commonSideEffects":[{"rate":"10-15","effect":"Bone marrow suppression (leukopenia, thrombocytopenia)"},{"rate":"10-15","effect":"Nausea and vomiting"},{"rate":"5-10","effect":"Hepatotoxicity"},{"rate":"5-10","effect":"Infection (due to immunosuppression)"},{"rate":"1-3","effect":"Pancreatitis"},{"rate":"1-5","effect":"Alopecia"},{"rate":"1-3","effect":"Rash"}]},"_chembl":{"chemblId":"CHEMBL1425","moleculeType":"Small molecule","molecularWeight":"152.18"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Both drugs are prodrugs/metabolites that interfere with purine metabolism, leading to decreased synthesis of DNA and RNA in rapidly dividing immune cells. This results in suppression of cell-mediated and humoral immunity, reducing inflammatory responses in autoimmune and inflammatory conditions. They are particularly effective at suppressing T-lymphocyte activation and proliferation.","oneSentence":"Azathioprine and 6-mercaptopurine are purine analogs that inhibit nucleotide synthesis and suppress T-cell and B-cell proliferation to reduce immune-mediated inflammation.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:27:58.379Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Inflammatory bowel disease (Crohn's disease and ulcerative colitis)"},{"name":"Rheumatoid arthritis"},{"name":"Autoimmune hepatitis"},{"name":"Systemic lupus erythematosus"},{"name":"Organ transplant rejection prevention"}]},"trialDetails":[{"nctId":"NCT07271069","phase":"","title":"Effectiveness of Ozanimod in Patients With Steroid-Dependent Ulcerative Colitis","status":"RECRUITING","sponsor":"Bristol-Myers Squibb","startDate":"2026-01-29","conditions":"Ulcerative Colitis (UC)","enrollment":150},{"nctId":"NCT06941376","phase":"PHASE2","title":"An Open-Label Study 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