{"id":"azacyclonol","rwe":[],"tags":[{"label":"azacyclonol","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Histamine H1 receptor","category":"target"},{"label":"HRH1","category":"gene"},{"label":"SCN1A","category":"gene"},{"label":"SCN2A","category":"gene"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{"commonSideEffects":[]},"trials":[],"aliases":[],"patents":[],"pricing":[],"_fixedAt":"2026-03-30T15:51:47.764584","allNames":"calmeran","offLabel":[],"synonyms":["azacyclonol","ataractan","calmeran","azacyclonol hydrochloride","frenquel","azacyclonol HCl"],"timeline":[],"aiSummary":"Calmeran is a small molecule with synonyms including Ataractan, AZACICLONOL, and Frenoton.","brandName":"Calmeran","ecosystem":[],"mechanism":{"target":"Histamine H1 receptor, Sodium channel alpha subunits; brain (Types I, II, III)","targets":[{"gene":"HRH1","source":"DrugCentral","target":"Histamine H1 receptor","protein":"Histamine H1 receptor","isPrimary":true,"activityType":"Ki","activityValue":6.18},{"gene":"SCN1A","source":"DrugCentral","target":"Sodium channel alpha subunits; brain (Types I, II, III)","protein":"Sodium channel protein type 1 subunit alpha"},{"gene":"SCN2A","source":"DrugCentral","target":"Sodium channel alpha subunits; brain (Types I, II, III)","protein":"Sodium channel protein type 2 subunit alpha"},{"gene":"SCN3A","source":"DrugCentral","target":"Sodium channel alpha subunits; brain (Types I, II, III)","protein":"Sodium channel protein type 3 subunit alpha"}],"modality":"Small Molecule","drugClass":"azacyclonol","explanation":"Imagine your body has a 'volume control' for histamine, a chemical that can cause allergic reactions and other issues. Calmeran acts like a 'mute button' for this volume control, reducing the effects of histamine and helping to alleviate symptoms. This can be especially helpful for people with allergies or other conditions where histamine plays a role.","oneSentence":"Calmeran works by blocking the histamine H1 receptor, which helps to reduce allergic responses and other physiological effects caused by histamine.","technicalDetail":"Calmeran exerts its effects by competitively binding to the histamine H1 receptor, thereby inhibiting the action of histamine and reducing its downstream effects on the body."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3680","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=AZACYCLONOL","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T08:47:39.807684","biosimilars":[],"competitors":[{"drugName":"acrivastine","drugSlug":"acrivastine","fdaApproval":"1994-03-25","relationship":"same-target"},{"drugName":"alcaftadine","drugSlug":"alcaftadine","fdaApproval":"2010-07-28","patentExpiry":"Mar 19, 2027","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"alimemazine","drugSlug":"alimemazine","fdaApproval":"","relationship":"same-target"},{"drugName":"amitriptyline","drugSlug":"amitriptyline","fdaApproval":"1961-04-07","genericCount":33,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"amoxapine","drugSlug":"amoxapine","fdaApproval":"1980-09-22","genericCount":3,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"antazoline","drugSlug":"antazoline","fdaApproval":"1990-04-30","relationship":"same-target"},{"drugName":"aripiprazole","drugSlug":"aripiprazole","fdaApproval":"2002-11-15","patentExpiry":"Sep 24, 2033","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"aripiprazole lauroxil","drugSlug":"aripiprazole-lauroxil","fdaApproval":"2015-10-05","patentExpiry":"Sep 8, 2035","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"asenapine","drugSlug":"asenapine","fdaApproval":"2009-08-13","patentExpiry":"Sep 22, 2033","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"astemizole","drugSlug":"astemizole","fdaApproval":"1988-12-31","relationship":"same-target"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"azacyclonol","indications":{"approved":[],"offLabel":[],"pipeline":[]},"_fixedFields":["primaryTarget"],"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"acrivastine","brandName":"acrivastine","genericName":"acrivastine","approvalYear":"1994","relationship":"same-target"},{"drugId":"alcaftadine","brandName":"alcaftadine","genericName":"alcaftadine","approvalYear":"2010","relationship":"same-target"},{"drugId":"alimemazine","brandName":"alimemazine","genericName":"alimemazine","approvalYear":"","relationship":"same-target"},{"drugId":"amitriptyline","brandName":"amitriptyline","genericName":"amitriptyline","approvalYear":"1961","relationship":"same-target"},{"drugId":"amoxapine","brandName":"amoxapine","genericName":"amoxapine","approvalYear":"1980","relationship":"same-target"},{"drugId":"antazoline","brandName":"antazoline","genericName":"antazoline","approvalYear":"1990","relationship":"same-target"},{"drugId":"aripiprazole","brandName":"aripiprazole","genericName":"aripiprazole","approvalYear":"2002","relationship":"same-target"},{"drugId":"aripiprazole-lauroxil","brandName":"aripiprazole lauroxil","genericName":"aripiprazole lauroxil","approvalYear":"2015","relationship":"same-target"},{"drugId":"asenapine","brandName":"asenapine","genericName":"asenapine","approvalYear":"2009","relationship":"same-target"},{"drugId":"astemizole","brandName":"astemizole","genericName":"astemizole","approvalYear":"1988","relationship":"same-target"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"UNII":"2MMR990PEM","CHEBI":"CHEBI:93706","INN_ID":"655","UMLSCUI":"C0175156","ChEMBL_ID":"CHEMBL127508","PUBCHEM_CID":"15723","SNOMEDCT_US":"3142009","SECONDARY_CAS_RN":"1798-50-1","MESH_SUPPLEMENTAL_RECORD_UI":"C100095"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":112,"therapeuticAreas":["Other"],"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}