{"id":"azacitidine-aza","safety":{"commonSideEffects":[{"rate":"60-80","effect":"Myelosuppression (anemia, thrombocytopenia, neutropenia)"},{"rate":"40-50","effect":"Nausea and vomiting"},{"rate":"30-40","effect":"Fatigue"},{"rate":"20-30","effect":"Fever"},{"rate":"10-20","effect":"Injection site reactions"},{"rate":"15-25","effect":"Constipation"}]},"_chembl":null,"_dailymed":{"setId":"71d8d758-86c9-b571-aed1-719654fd4b82","title":"AZACITIDINE INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION [DR. REDDY'S LABORATORIES INC.]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Azacitidine is a nucleoside analog that incorporates into DNA and inhibits DNA methyltransferase (DNMT), reducing aberrant DNA methylation in cancer cells. This demethylation reactivates epigenetically silenced tumor suppressor genes and can induce differentiation and apoptosis in myelodysplastic and leukemic cells. It is thought to restore normal gene expression patterns disrupted by hypermethylation in hematologic malignancies.","oneSentence":"Azacitidine inhibits DNA methyltransferase, leading to DNA demethylation and reactivation of silenced tumor suppressor genes.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:03:16.706Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Myelodysplastic syndromes (MDS)"},{"name":"Acute myeloid leukemia (AML)"},{"name":"Chronic myelomonocytic leukemia (CMML)"}]},"trialDetails":[{"nctId":"NCT06514261","phase":"PHASE1","title":"Testing the Combination of an Anti-Cancer Drug, Iadademstat, With Other Anti-Cancer Drugs (Venetoclax and Azacitidine) for Treating AML","status":"RECRUITING","sponsor":"National Cancer Institute (NCI)","startDate":"2024-12-18","conditions":"Acute Myeloid Leukemia","enrollment":45},{"nctId":"NCT04284787","phase":"PHASE2","title":"BLAST MRD AML-2: BLockade of PD-1 Added to Standard Therapy to 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