{"id":"avova-1","safety":{"commonSideEffects":[]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"AVOVA-1 consists of mesenchymal stem cells or similar regenerative cells sourced from umbilical cord tissue. These cells are believed to work through immunomodulatory and paracrine mechanisms, secreting anti-inflammatory factors and promoting endogenous repair processes. The therapy is designed to address degenerative or inflammatory conditions by enhancing tissue healing and reducing pathological inflammation.","oneSentence":"AVOVA-1 is an allogeneic cell therapy derived from umbilical cord tissue that aims to promote tissue regeneration and reduce inflammation.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T03:57:42.717Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Osteoarthritis or joint degenerative disease (investigational)"}]},"trialDetails":[{"nctId":"NCT02033616","phase":"PHASE2","title":"Autologous Dendritic Cells Loaded With Autologous Tumor Associated Antigens for Treatment of Advanced Epithelial Ovarian Carcinomas","status":"UNKNOWN","sponsor":"Aivita Biomedical, Inc.","startDate":"2017-11-18","conditions":"Stage III Ovarian Carcinoma, Stage IV Ovarian Carcinoma, Fallopian Tube Carcinoma","enrollment":99}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_2","status":"active","brandName":"AVOVA-1","genericName":"AVOVA-1","companyName":"Aivita Biomedical, Inc.","companyId":"aivita-biomedical-inc","modality":"Biologic","firstApprovalDate":"","aiSummary":"AVOVA-1 is an allogeneic cell therapy derived from umbilical cord tissue that aims to promote tissue regeneration and reduce inflammation. Used for Osteoarthritis or joint degenerative disease (investigational).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":true,"score":3}}