{"id":"avonex-zocor","safety":{"commonSideEffects":[{"rate":"~76%","effect":"Flu-like symptoms (Avonex)"},{"rate":"~28%","effect":"Injection site reactions (Avonex)"},{"rate":"~25%","effect":"Myalgia (Avonex)"},{"rate":"~3-5%","effect":"Muscle pain/myopathy (Zocor)"},{"rate":"~1-3%","effect":"Elevated liver enzymes (Zocor)"}]},"_chembl":{"chemblId":"CHEMBL1201562","moleculeType":"Protein"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Avonex is a recombinant interferon beta-1a that acts as an immunomodulator, reducing inflammatory responses and T-cell proliferation in multiple sclerosis. Zocor is a statin that competitively inhibits HMG-CoA reductase, the rate-limiting enzyme in cholesterol synthesis, thereby reducing LDL cholesterol levels. These are distinct drugs with different mechanisms and therapeutic targets.","oneSentence":"This is a combination of two separate marketed drugs: Avonex (interferon beta-1a) which modulates immune response in multiple sclerosis, and Zocor (simvastatin) which inhibits HMG-CoA reductase to lower cholesterol.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:22:29.969Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Relapsing-remitting multiple sclerosis (Avonex component)"},{"name":"Hypercholesterolemia and cardiovascular disease prevention (Zocor component)"}]},"trialDetails":[{"nctId":"NCT02735707","phase":"PHASE3","title":"Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia","status":"RECRUITING","sponsor":"UMC Utrecht","startDate":"2016-04-11","conditions":"Community-acquired Pneumonia, Influenza, COVID-19","enrollment":20000},{"nctId":"NCT00492765","phase":"PHASE4","title":"Simvastatin as an Add-on Treatment to Interferon-beta-1a for the Treatment of Relapsing-Remitting Multiple Sclerosis","status":"COMPLETED","sponsor":"Biogen","startDate":"2006-02","conditions":"Multiple Sclerosis","enrollment":380},{"nctId":"NCT00668343","phase":"PHASE3","title":"Simvastatin in Relapsing Remitting Multiple Sclerosis (RRMS) Patients Using Avonex Compared to Placebo","status":"COMPLETED","sponsor":"Tehran University of Medical Sciences","startDate":"2005-04","conditions":"Relapsing Remitting Multiple Sclerosis","enrollment":80},{"nctId":"NCT00146068","phase":"PHASE4","title":"EARLY IFNB-1a and Simvastatin Combination Therapy in Clinically Isolated Syndrome Suggestive of Multiple Sclerosis","status":"COMPLETED","sponsor":"University of North Carolina","startDate":"2004-09","conditions":"Multiple Sclerosis","enrollment":30},{"nctId":"NCT00242268","phase":"PHASE3","title":"A Safety Study of Combination Treatment With Avonex and Zocor in Relapsing Remitting Multiple Sclerosis","status":"UNKNOWN","sponsor":"Alabama Neurology Associates, PC","startDate":"2005-10","conditions":"Relapsing Remitting Multiple Sclerosis","enrollment":30}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Avonex/Zocor","genericName":"Avonex/Zocor","companyName":"University of North Carolina","companyId":"university-of-north-carolina","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This is a combination of two separate marketed drugs: Avonex (interferon beta-1a) which modulates immune response in multiple sclerosis, and Zocor (simvastatin) which inhibits HMG-CoA reductase to lower cholesterol. Used for Relapsing-remitting multiple sclerosis (Avonex component), Hypercholesterolemia and cardiovascular disease prevention (Zocor component).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}