{"id":"av7909","safety":{"commonSideEffects":[{"rate":null,"effect":"Injection site reactions (erythema, induration, pain)"},{"rate":null,"effect":"Myalgia"},{"rate":null,"effect":"Fatigue"},{"rate":null,"effect":"Headache"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"AV7909 is an improved formulation of anthrax vaccine adsorbed (AVA) that combines recombinant protective antigen with a novel adjuvant to enhance immunogenicity and reduce the number of doses required for protection. The vaccine works by priming both humoral and cellular immune responses against anthrax protective antigen, enabling the immune system to neutralize anthrax toxins and prevent infection.","oneSentence":"AV7909 is an anthrax vaccine that stimulates immune responses against anthrax toxins through a combination of protective antigen and adjuvant components.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:03:01.928Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prophylaxis of anthrax infection in at-risk populations"},{"name":"Post-exposure prophylaxis following anthrax exposure"}]},"trialDetails":[{"nctId":"NCT05997264","phase":"PHASE2","title":"Anthrax AV7909 Boost Evaluation Study","status":"ACTIVE_NOT_RECRUITING","sponsor":"Biomedical Advanced Research and Development Authority","startDate":"2023-12-05","conditions":"Anthrax","enrollment":220},{"nctId":"NCT04067011","phase":"PHASE2","title":"Velocity 2: An Anthrax Vaccine and Antibiotics Clinical Study","status":"COMPLETED","sponsor":"Emergent BioSolutions","startDate":"2019-08-12","conditions":"Anthrax","enrollment":210},{"nctId":"NCT04660201","phase":"PHASE1","title":"Anthrax AV7909 Liquid vs Lyophilized","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"2022-05-25","conditions":"Anthrax, Anthrax Immunisation","enrollment":41},{"nctId":"NCT03877926","phase":"PHASE3","title":"VELOCITY: An Anthrax Vaccine Clinical Study","status":"COMPLETED","sponsor":"Emergent BioSolutions","startDate":"2019-03-11","conditions":"Anthrax","enrollment":3862},{"nctId":"NCT01263691","phase":"PHASE1","title":"Safety, Tolerability and Immunogenicity Study of AV7909 Anthrax Vaccine in Healthy Adults","status":"COMPLETED","sponsor":"Emergent BioSolutions","startDate":"2010-12","conditions":"Bacillus Anthracis (Anthrax) Infection","enrollment":105},{"nctId":"NCT01770743","phase":"PHASE2","title":"A Phase 2 Safety and Immunogenicity Study for an Anthrax Vaccine Using 3 Schedules and Two Dose Levels","status":"COMPLETED","sponsor":"Emergent BioSolutions","startDate":"2013-01","conditions":"Anthrax","enrollment":168},{"nctId":"NCT03518125","phase":"PHASE2","title":"BARDA Securing Anthrax Immunity For the Elderly","status":"COMPLETED","sponsor":"Biomedical Advanced Research and Development Authority","startDate":"2018-05-09","conditions":"Anthrax","enrollment":305}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":15,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["AV7909 Anthrax Vaccine Adsorbed","NuThrax","AV7909 Anthrax Vaccine"],"phase":"phase_3","status":"active","brandName":"AV7909","genericName":"AV7909","companyName":"Biomedical Advanced Research and Development Authority","companyId":"biomedical-advanced-research-and-development-authority","modality":"Biologic","firstApprovalDate":"","aiSummary":"AV7909 is an anthrax vaccine that stimulates immune responses against anthrax toxins through a combination of protective antigen and adjuvant components. Used for Prophylaxis of anthrax infection in at-risk populations, Post-exposure prophylaxis following anthrax exposure.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":4,"withResults":4},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}