{"id":"autologous-intrathecal-hematopoietic-stem-cells","safety":{"commonSideEffects":[{"rate":null,"effect":"Injection site pain or discomfort"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Fever"},{"rate":null,"effect":"Infection at injection site"}]},"_chembl":{"chemblId":"CHEMBL5315099","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This cell therapy involves collecting the patient's own bone marrow-derived hematopoietic stem cells, which are then administered directly into the intrathecal space (around the spinal cord). These stem cells are believed to promote neuroprotection, reduce inflammation, and stimulate endogenous repair mechanisms in neurological tissues. The autologous approach minimizes immunological rejection while leveraging the regenerative potential of stem cells.","oneSentence":"Autologous hematopoietic stem cells are harvested from the patient, processed, and reinfused intrathecally into the cerebrospinal fluid to promote neural repair and regeneration.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:42:14.634Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Spinal cord injury"},{"name":"Amyotrophic lateral sclerosis (ALS)"}]},"trialDetails":[{"nctId":"NCT07495631","phase":"NA","title":"Pediatric-Inspired Regimen Combined With Venetoclax and Immunotherapy for Adult Ph-Negative Acute Lymphoblastic Leukemia","status":"NOT_YET_RECRUITING","sponsor":"Institute of Hematology & Blood Diseases Hospital, China","startDate":"2026-03-01","conditions":"Acute Lymphoblastic Leukemia, Adult","enrollment":80},{"nctId":"NCT06942039","phase":"EARLY_PHASE1","title":"Pilot Study of IT Topotecan and Maintenance Chemotherapy for HR-EBTs in Children < 6 Years, Post Consolidation","status":"RECRUITING","sponsor":"C17 Council","startDate":"2025-09-23","conditions":"CNS Embryonal Tumor, CNS, Medulloblastoma, Atypical Teratoid Rhabdoid Tumor","enrollment":15},{"nctId":"NCT01740869","phase":"PHASE3","title":"Autologous Bone Marrow Stem Cells for Children With Autism Spectrum Disorders","status":"COMPLETED","sponsor":"Hospital Universitario Dr. Jose E. Gonzalez","startDate":"2012-11","conditions":"Autism, Autism Spectrum","enrollment":30},{"nctId":"NCT00002768","phase":"PHASE2","title":"Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Acute Myeloid Leukemia in Second Remission","status":"COMPLETED","sponsor":"Alliance for Clinical Trials in Oncology","startDate":"1996-06","conditions":"Leukemia","enrollment":51},{"nctId":"NCT01933321","phase":"PHASE2, PHASE3","title":"Effect of Intrathecal Administration of Hematopoietic Stem Cells in Patients With Amyotrophic Lateral Sclerosis (ALS)","status":"COMPLETED","sponsor":"Hospital Universitario Dr. Jose E. Gonzalez","startDate":"2012-09","conditions":"Amyotrophic Lateral Sclerosis","enrollment":14}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Autologous Intrathecal Hematopoietic Stem Cells","genericName":"Autologous Intrathecal Hematopoietic Stem Cells","companyName":"Hospital Universitario Dr. Jose E. Gonzalez","companyId":"hospital-universitario-dr-jose-e-gonzalez","modality":"Biologic","firstApprovalDate":"","aiSummary":"Autologous hematopoietic stem cells are harvested from the patient, processed, and reinfused intrathecally into the cerebrospinal fluid to promote neural repair and regeneration. Used for Spinal cord injury, Amyotrophic lateral sclerosis (ALS).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}