{"id":"attenuated-hav-vaccine-l-a-1-strain","safety":{"commonSideEffects":[{"rate":null,"effect":"Local injection site reactions (pain, erythema, swelling)"},{"rate":null,"effect":"Fever"},{"rate":null,"effect":"Gastrointestinal symptoms (diarrhea, nausea)"},{"rate":null,"effect":"Fatigue"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The L-A-1 strain is a live attenuated hepatitis A virus vaccine that replicates in the gastrointestinal tract and induces both humoral (antibody) and cellular immune responses. The weakened virus triggers the production of neutralizing antibodies and memory B and T cells, providing long-term protection against wild-type hepatitis A virus infection without causing hepatitis.","oneSentence":"This attenuated live vaccine stimulates immune responses against hepatitis A virus by introducing a weakened form of the virus that replicates in the body without causing disease.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:42:50.706Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of hepatitis A infection"}]},"trialDetails":[{"nctId":"NCT01949857","phase":"PHASE4","title":"The Immunogenicity and Safety of Inactivated and Live Attenuated Hepatitis A Vaccines","status":"COMPLETED","sponsor":"Institute of Medical Biology, Chinese Academy of Medical Sciences","startDate":"2013-09","conditions":"Hepatitis A","enrollment":35000}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Hepatitis A Vaccine"],"phase":"marketed","status":"active","brandName":"Attenuated HAV Vaccine, L-A-1 Strain","genericName":"Attenuated HAV Vaccine, L-A-1 Strain","companyName":"Institute of Medical Biology, Chinese Academy of Medical Sciences","companyId":"institute-of-medical-biology-chinese-academy-of-medical-sciences","modality":"Biologic","firstApprovalDate":"","aiSummary":"This attenuated live vaccine stimulates immune responses against hepatitis A virus by introducing a weakened form of the virus that replicates in the body without causing disease. Used for Prevention of hepatitis A infection.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}