{"id":"atropine-sulfate-eye-drops-0-02","safety":{"commonSideEffects":[{"rate":null,"effect":"Mydriasis (pupil dilation)"},{"rate":null,"effect":"Cycloplegia (accommodation paralysis)"},{"rate":null,"effect":"Photophobia (light sensitivity)"},{"rate":null,"effect":"Blurred vision"},{"rate":null,"effect":"Ocular irritation or discomfort"}]},"_chembl":{"chemblId":"CHEMBL1396281","moleculeType":"Small molecule","molecularWeight":"387.45"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Atropine is an anticholinergic agent that competitively antagonizes muscarinic receptors on the ciliary muscle and iris sphincter muscle. By blocking acetylcholine signaling, it prevents accommodation (lens thickening) and causes mydriasis (pupil dilation). In pediatric myopia, low-dose atropine is thought to work through multiple mechanisms including reduced accommodation-induced axial elongation and potential direct effects on scleral remodeling.","oneSentence":"Atropine blocks muscarinic acetylcholine receptors in the eye to dilate the pupil and paralyze accommodation, slowing myopia progression in children.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:02:53.434Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Myopia progression control in children (Phase 3)"}]},"trialDetails":[{"nctId":"NCT06523504","phase":"PHASE1, PHASE2","title":"Atropine (0.02%, 0.04%) Combined With Defocus DIMS for Moderate and High Myopia Control","status":"RECRUITING","sponsor":"Ruihua Wei","startDate":"2024-02-01","conditions":"Myopia","enrollment":410},{"nctId":"NCT03865160","phase":"PHASE2, PHASE3","title":"Low-dose Atropine for Myopia Control in Children","status":"ACTIVE_NOT_RECRUITING","sponsor":"University Eye Hospital, Freiburg","startDate":"2021-10-19","conditions":"Myopia, Progressive","enrollment":302},{"nctId":"NCT06708156","phase":"PHASE3","title":"The Effectiveness and Safety of Two Low-concentration Atropine Sulfate Eye Drops (0.01%/0.02%) for Delaying the Pediatric Myopia Progression","status":"RECRUITING","sponsor":"Oupushifang Pharmaceutical Technology Co., Ltd.","startDate":"2024-06-15","conditions":"Myopia, Myopia Progression","enrollment":606},{"nctId":"NCT05939882","phase":"NA","title":"Low Concentration Atropine in the Prevention of Myopia in Children.","status":"UNKNOWN","sponsor":"Shanghai Eye Disease Prevention and Treatment Center","startDate":"2023-04-01","conditions":"Myopia, Progressive","enrollment":428},{"nctId":"NCT03690414","phase":"PHASE1","title":"Evaluation of Short Term Use of Experimental Eye Drops BHVI2, 0.02% Atropine and BHVI2 Plus 0.02% Atropine Eye Drops","status":"COMPLETED","sponsor":"Hai Yen Eye Care","startDate":"2018-10-01","conditions":"Myopia","enrollment":52},{"nctId":"NCT03699423","phase":"PHASE1","title":"Effects of Low Concentration Atropine on Pupillary Size and Accommodative Amplitude","status":"COMPLETED","sponsor":"Hai Yen Eye Care","startDate":"2018-03-08","conditions":"Myopia","enrollment":58}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":45,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Atropine sulfate eye drops 0.02%","genericName":"Atropine sulfate eye drops 0.02%","companyName":"Oupushifang Pharmaceutical Technology Co., Ltd.","companyId":"oupushifang-pharmaceutical-technology-co-ltd","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Atropine blocks muscarinic acetylcholine receptors in the eye to dilate the pupil and paralyze accommodation, slowing myopia progression in children. Used for Myopia progression control in children (Phase 3).","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}