{"id":"atropine-sulfate-1-oph-soln","safety":{"commonSideEffects":[{"rate":null,"effect":"Blurred vision"},{"rate":null,"effect":"Photophobia"},{"rate":null,"effect":"Eye irritation or discomfort"},{"rate":null,"effect":"Systemic anticholinergic effects (rare with topical use)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Atropine is an anticholinergic agent that competitively antagonizes muscarinic receptors on the iris sphincter muscle and ciliary muscle. This prevents parasympathetic-mediated pupil constriction and lens accommodation, resulting in mydriasis (pupil dilation) and cycloplegia (paralysis of accommodation). In ophthalmology, these effects are used diagnostically and therapeutically.","oneSentence":"Atropine blocks muscarinic acetylcholine receptors in the eye to dilate the pupil and paralyze accommodation.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:19:45.207Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Mydriasis and cycloplegia for refraction and diagnostic examination"},{"name":"Uveitis and iritis"},{"name":"Accommodative esotropia"},{"name":"Myopia control (off-label use in some regions)"}]},"trialDetails":[{"nctId":"NCT03158142","phase":"PHASE4","title":"The Influence of Atropine on Choroidal Thickness","status":"COMPLETED","sponsor":"State University of New York College of Optometry","startDate":"2017-03-15","conditions":"Myopia","enrollment":32}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["1% atropine eye drops"],"phase":"marketed","status":"active","brandName":"Atropine Sulfate 1% Oph Soln","genericName":"Atropine Sulfate 1% Oph Soln","companyName":"State University of New York College of Optometry","companyId":"state-university-of-new-york-college-of-optometry","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Atropine blocks muscarinic acetylcholine receptors in the eye to dilate the pupil and paralyze accommodation. Used for Mydriasis and cycloplegia for refraction and diagnostic examination, Uveitis and iritis, Accommodative esotropia.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}