{"id":"atropine-oxyde","rwe":[{"pmid":"35880679","year":"2022","title":"Pharmacological evidence that GABA-induced relaxation of rat proximal duodenum longitudinal muscle depends on NKCC cotransporter activity and Ca(2+) influx.","finding":"","journal":"Canadian journal of physiology and pharmacology","studyType":"Clinical Study"}],"tags":[{"label":"atropine oxyde","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"}],"phase":"unknown","safety":{"commonSideEffects":[]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"genatropine","offLabel":[],"synonyms":["aminoxytropine tropate","atropine aminoxide","atropine oxide","genatropine","Atropine N-oxide","atropine oxyde"],"timeline":[],"brandName":"Genatropine","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"atropine oxyde","explanation":"Think of acetylcholine like a messenger that helps different parts of your body talk to each other. When acetylcholine is blocked, it can affect how your body responds to certain stimuli, such as muscle contractions or heart rate. This can be useful in treating certain medical conditions, but it can also cause side effects if not used carefully.","oneSentence":"Genatropine works by blocking the action of acetylcholine, a neurotransmitter that helps transmit signals in the nervous system.","technicalDetail":"Genatropine is a competitive antagonist of the muscarinic acetylcholine receptor, which is a subtype of acetylcholine receptor found in the nervous system. By blocking this receptor, genatropine can reduce the effects of acetylcholine and alter the activity of various bodily functions, including heart rate, digestion, and muscle contractions."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/261","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=atropine oxyde","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T08:51:05.327430","biosimilars":[],"competitors":[],"genericName":"atropine oxyde","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"3Y03IC177D","CHEBI":"CHEBI:135298","INN_ID":"1297","UMLSCUI":"C5238093","ChEMBL_ID":"CHEMBL2146145","KEGG_DRUG":"D07477","PUBCHEM_CID":"3000668"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":1,"therapeuticAreas":["Neuroscience"],"biosimilarFilings":[],"recentPublications":[{"date":"2022 Aug 1","pmid":"35880679","title":"Pharmacological evidence that GABA-induced relaxation of rat proximal duodenum longitudinal muscle depends on NKCC cotransporter activity and Ca(2+) influx.","journal":"Canadian journal of physiology and pharmacology"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Genatropine, also known as atropine oxyde, is a small molecule drug in the atropine oxyde class. Its exact target and mechanism of action are unknown, but it is believed to work by blocking the action of acetylcholine, a neurotransmitter that plays a key role in various bodily functions. Genatropine is not FDA-approved for any indications, and its commercial status, including patent status and generic availability, is unclear. As a result, there is limited information available on its safety profile and potential side effects. Further research is needed to fully understand the properties and potential uses of genatropine.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}