{"id":"atropine-0-04","safety":{"commonSideEffects":[{"rate":null,"effect":"Blurred vision"},{"rate":null,"effect":"Photophobia (light sensitivity)"},{"rate":null,"effect":"Eye irritation or discomfort"},{"rate":null,"effect":"Increased intraocular pressure"},{"rate":null,"effect":"Systemic anticholinergic effects (dry mouth, tachycardia) if absorbed"}]},"_chembl":{"chemblId":"CHEMBL4557433","moleculeType":"Unknown","molecularWeight":"289.38"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Atropine is an anticholinergic agent that competitively antagonizes acetylcholine at muscarinic receptors throughout the body. By blocking these receptors, it reduces parasympathetic effects including pupil constriction, accommodation, and excessive salivation or secretions. The 0.04% ophthalmic formulation is primarily used to dilate the pupil and relax the ciliary muscle for diagnostic and therapeutic purposes.","oneSentence":"Atropine blocks muscarinic acetylcholine receptors to inhibit parasympathetic nervous system activity.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:19:37.243Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Mydriasis (pupil dilation) for ophthalmic examination"},{"name":"Cycloplegia (ciliary muscle paralysis) for refraction testing"},{"name":"Myopia control in children"}]},"trialDetails":[{"nctId":"NCT04699357","phase":"NA","title":"The Effect and Safety of Different Doses of Atropine on Myopic Progression of Highly Myopic Children: Multi-centered Randomized Clinical Trial","status":"COMPLETED","sponsor":"Shanghai Eye Disease Prevention and Treatment Center","startDate":"2021-07-04","conditions":"High Myopia","enrollment":219},{"nctId":"NCT07406399","phase":"PHASE4","title":"Low Concentration Atropine Combined With Soft Contact Lens in Controlling Myopia Progression in Children With High Myopia","status":"COMPLETED","sponsor":"Beijing Tongren Hospital","startDate":"2023-06-30","conditions":"High Myopia, Low Concentration Atropine, Soft Contact Lens","enrollment":120},{"nctId":"NCT00608725","phase":"NA","title":"Pathophysiology of Orthostatic Intolerance","status":"ACTIVE_NOT_RECRUITING","sponsor":"Satish R. 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Used for Mydriasis (pupil dilation) for ophthalmic examination, Cycloplegia (ciliary muscle paralysis) for refraction testing, Myopia control in children.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}