{"id":"atrolactamide","rwe":[],"tags":[{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"}],"phase":"unknown","safety":{"commonSideEffects":[]},"trials":[],"aliases":[],"patents":[],"pricing":[],"_fixedAt":"2026-03-30T16:33:32.466389","allNames":"themisone","offLabel":[],"synonyms":["atrolactamide","themisone","2-Hydroxy-2-phenylpropionamide","2-Hydroxy-2-phenylpropylamide","2-Phenyl-2-hydroxypropionamide","DL-Atrolactamide"],"timeline":[],"brandName":"Themisone","ecosystem":[],"mechanism":{"modality":"Small Molecule","explanation":"Imagine your body's cells have locks on them, and Themisone is a key that fits into one of those locks. When it binds to the lock, it sends a signal that helps to treat a particular condition. This is a simplified explanation of how Themisone works at a molecular level.","oneSentence":"Themisone (atrolactamide) is thought to work by interacting with a specific biological target to produce a therapeutic effect.","technicalDetail":"Atrolactamide is a small molecule that binds to a specific protein or receptor, altering its activity and leading to a therapeutic response."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3679","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=atrolactamide","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T08:47:03.600716","biosimilars":[],"competitors":[],"genericName":"atrolactamide","indications":{"approved":[],"offLabel":[],"pipeline":[]},"_fixedFields":["pubmed(4)"],"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"SJ9132S4AW","CHEBI":"CHEBI:134797","ChEMBL_ID":"CHEMBL309487","PUBCHEM_CID":"16235"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":4,"therapeuticAreas":["Other"],"biosimilarFilings":[],"recentPublications":[{"date":"2012 Jan","pmid":"22020513","title":"Conversion of sterically demanding α,α-disubstituted phenylacetonitriles by the arylacetonitrilase from Pseudomonas fluorescens EBC191.","journal":"Applied and environmental microbiology"},{"date":"2004 Mar 1","pmid":"14980611","title":"Design, synthesis and evaluation of novel hydroxyamides as orally available anticonvulsants.","journal":"Bioorganic & medicinal chemistry"},{"date":"1955 Apr","pmid":"14368513","title":"Atrolactamide: its absorption, distribution and excretion.","journal":"The Journal of pharmacology and experimental therapeutics"},{"date":"1953 Oct","pmid":"13097345","title":"Atrolactamide (themisone, M-144); its determination, absorption and excretion.","journal":"The Journal of pharmacology and experimental therapeutics"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Themisone is a small molecule. Its modality is classified as a small molecule according to ChEMBL.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}