{"id":"atracurium-tbw","safety":{"commonSideEffects":[{"rate":null,"effect":"Histamine release (flushing, hypotension, tachycardia)"},{"rate":null,"effect":"Prolonged neuromuscular blockade"},{"rate":null,"effect":"Anaphylaxis"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Atracurium binds to nicotinic acetylcholine receptors at the motor end plate, preventing acetylcholine from binding and blocking neuromuscular transmission. This results in flaccid paralysis of skeletal muscles. Atracurium is unique in that it undergoes Hofmann elimination (temperature and pH-dependent degradation) and ester hydrolysis, making it suitable for patients with hepatic or renal impairment.","oneSentence":"Atracurium is a non-depolarizing neuromuscular blocking agent that competitively antagonizes acetylcholine at the neuromuscular junction to produce muscle paralysis.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:27:53.904Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Muscle relaxation during anesthesia for surgical procedures"},{"name":"Facilitation of endotracheal intubation"}]},"trialDetails":[{"nctId":"NCT01097148","phase":"PHASE4","title":"Peri -and Postoperative Drug Therapy Schedules for Morbidly Obese Patients","status":"COMPLETED","sponsor":"St. Antonius Hospital","startDate":"2009-11","conditions":"Obese, Atracurium, Cefazolin","enrollment":20}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":3,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Atracurium, TBW","genericName":"Atracurium, TBW","companyName":"St. Antonius Hospital","companyId":"st-antonius-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Atracurium is a non-depolarizing neuromuscular blocking agent that competitively antagonizes acetylcholine at the neuromuscular junction to produce muscle paralysis. Used for Muscle relaxation during anesthesia for surgical procedures, Facilitation of endotracheal intubation.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}