{"id":"atg","safety":{"commonSideEffects":[{"rate":null,"effect":"Fever"},{"rate":null,"effect":"Chills"},{"rate":null,"effect":"Leukopenia"},{"rate":null,"effect":"Thrombocytopenia"},{"rate":null,"effect":"Infection"},{"rate":null,"effect":"Serum sickness"},{"rate":null,"effect":"Infusion reactions"}]},"_chembl":{"chemblId":"CHEMBL4482864","moleculeType":"Small molecule","molecularWeight":"494.51"},"_dailymed":{"setId":"d77aa596-910d-516b-e053-2995a90a0839","title":"POMBILITI ATGA (CIPAGLUCOSIDASE ALFA-ATGA) INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION [AMICUS THERAPEUTICS US, LLC]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"ATG works by targeting and eliminating T cells, which are key drivers of immune-mediated rejection and autoimmune responses. It is produced by immunizing animals (typically rabbits or horses) against human thymus cells, generating a mixture of antibodies against various T-cell surface antigens. This T-cell depletion reduces the immune response in transplant rejection and certain autoimmune conditions.","oneSentence":"ATG (Antithymocyte Globulin) is a polyclonal antibody that depletes T lymphocytes by binding to T-cell antigens and triggering their destruction.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:26:24.367Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of acute organ rejection in renal transplant recipients"},{"name":"Treatment of acute rejection episodes in renal transplant recipients"},{"name":"Aplastic anemia (severe)"}]},"trialDetails":[{"nctId":"NCT07412470","phase":"PHASE2, PHASE3","title":"A Study to Investigate the Efficacy and Safety of Frexalimab Versus Tacrolimus in Adults Undergoing Kidney Transplantation","status":"RECRUITING","sponsor":"Sanofi","startDate":"2026-03-13","conditions":"Kidney Transplant Rejection","enrollment":526},{"nctId":"NCT04464434","phase":"PHASE4","title":"Upfront 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