{"id":"atazanavir-ritonavir","brandName":"Atazanavir ritonavir","genericName":"Atazanavir ritonavir","companyId":"g-teborg-university","companyName":"Göteborg University","phase":"marketed","status":"active","modality":"Small molecule","aliases":[],"developmentCodes":[],"firstApprovalDate":null,"firstApprovalCountry":null,"aiSummary":"Atazanavir ritonavir is a combination antiretroviral therapy used for treating HIV. It has shown efficacy in multiple clinical trials, including pediatric populations. The drug is well-tolerated but has specific safety considerations, particularly in pregnant women and those with renal impairment.","enrichmentLevel":3,"visitCount":0,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Atazanavir binds to and inhibits HIV protease, an enzyme essential for processing viral precursor proteins into functional components required for infectious particle assembly. Ritonavir, a potent CYP3A4 inhibitor, is co-administered at low dose to dramatically increase atazanavir plasma concentrations and half-life, allowing for once-daily dosing and improved efficacy. Together, they suppress HIV replication by preventing the formation of mature, infectious viral particles.","oneSentence":"Atazanavir is a protease inhibitor that blocks HIV protease, preventing viral polyprotein cleavage and maturation; ritonavir is a booster that inhibits cytochrome P450 metabolism to increase atazanavir levels.","_ai_confidence":"high"},"administration":{},"safety":{"commonSideEffects":[{"rate":"40-50","effect":"Hyperbilirubinemia"},{"rate":"5-10","effect":"Jaundice"},{"rate":"10-15","effect":"Nausea"},{"rate":"10-15","effect":"Diarrhea"},{"rate":"5-10","effect":"Headache"},{"rate":"5-10","effect":"Rash"},{"rate":"1-2","effect":"Nephrolithiasis"}]},"trials":[],"indications":{"approved":[{"name":"HIV-1 infection in treatment-naïve and treatment-experienced adults"},{"name":"HIV-1 infection in combination antiretroviral therapy"}]},"commercial":null,"patents":[],"timeline":[],"rwe":[],"competitors":[],"ownershipHistory":[],"trialDetails":[],"genericFilers":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"labelChanges":[],"nice":null,"revenue":null,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":false,"score":3}}