{"id":"astx727","safety":{"commonSideEffects":[{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Vomiting"},{"rate":null,"effect":"Diarrhea"},{"rate":null,"effect":"Constipation"},{"rate":null,"effect":"Fatigue"},{"rate":null,"effect":"Thrombocytopenia"},{"rate":null,"effect":"Neutropenia"},{"rate":null,"effect":"Anemia"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Decitabine is a hypomethylating agent that inhibits DNA methyltransferase, leading to demethylation of DNA and reactivation of aberrantly silenced genes. Cedazuridine is a cytidine deaminase inhibitor that increases decitabine bioavailability by preventing its degradation, allowing for oral administration instead of intravenous infusion. 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