{"id":"astrazenica-vaccine","safety":{"commonSideEffects":[{"rate":"~50","effect":"Injection site pain"},{"rate":"~40","effect":"Fatigue"},{"rate":"~35","effect":"Headache"},{"rate":"~25","effect":"Myalgia"},{"rate":"~15","effect":"Fever"},{"rate":"~10","effect":"Chills"}]},"_chembl":{"chemblId":"CHEMBL2108573","moleculeType":"Vaccine component"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The vaccine employs a viral vector platform where a modified adenovirus carries genetic instructions for producing the spike protein of SARS-CoV-2. Once administered, the vector enters cells and directs production of the spike protein, which the immune system recognizes as foreign and mounts both cellular and humoral immune responses. This approach generates antibodies and T-cell immunity without using the live virus itself.","oneSentence":"The AstraZeneca COVID-19 vaccine (ChAdOx1 nCoV-19) uses a replication-deficient chimpanzee adenovirus vector to deliver the SARS-CoV-2 spike protein gene, triggering immune responses against the virus.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:42:09.748Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"COVID-19 prevention in adults and adolescents"}]},"trialDetails":[{"nctId":"NCT05017792","phase":"PHASE3","title":"Evaluation of Clinical and Antibody Response to Covid-19 Vaccination Strategy in TBRI, Egypt","status":"UNKNOWN","sponsor":"Samia Hassan El-Shishtawy","startDate":"2021-08-30","conditions":"Covid19","enrollment":200}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Astrazenica vaccine","genericName":"Astrazenica vaccine","companyName":"Samia Hassan El-Shishtawy","companyId":"samia-hassan-el-shishtawy","modality":"Biologic","firstApprovalDate":"","aiSummary":"The AstraZeneca COVID-19 vaccine (ChAdOx1 nCoV-19) uses a replication-deficient chimpanzee adenovirus vector to deliver the SARS-CoV-2 spike protein gene, triggering immune responses against the virus. Used for COVID-19 prevention in adults and adolescents.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}