{"id":"assigned-pulmonary-hypertension-medication","safety":{"commonSideEffects":[{"rate":"null","effect":"Headache"},{"rate":"null","effect":"Dizziness"},{"rate":"null","effect":"Nausea"}]},"_chembl":{"chemblId":"CHEMBL957","moleculeType":"Small molecule","molecularWeight":"551.63"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Endothelin-1 is a peptide that causes blood vessels to constrict, leading to increased blood pressure. By inhibiting endothelin-1, this drug helps to relax blood vessels and reduce blood pressure.","oneSentence":"This drug works by inhibiting the action of endothelin-1, a potent vasoconstrictor.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T03:21:30.645Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Treatment of pulmonary arterial hypertension"}]},"trialDetails":[{"nctId":"NCT02932410","phase":"PHASE3","title":"A Study to Assess Whether Macitentan Delays Disease Progression in Children With Pulmonary Arterial Hypertension (PAH)","status":"COMPLETED","sponsor":"Actelion","startDate":"2017-10-24","conditions":"Pulmonary Arterial Hypertension","enrollment":165},{"nctId":"NCT06899815","phase":"PHASE1","title":"Preliminary Human Trials of F230 Tablets","status":"RECRUITING","sponsor":"Beijing Continent Pharmaceutical Co, Ltd.","startDate":"2025-05-15","conditions":"Pulmonary Hypertension","enrollment":136},{"nctId":"NCT06458218","phase":"NA","title":"Impact of Multi-component Interventions on Populations With Mental Health Symptoms and High-risk COPD","status":"ACTIVE_NOT_RECRUITING","sponsor":"Peking Union Medical College","startDate":"2024-06-17","conditions":"Multimorbidity, Mental Health Issue, Multi-component Interventions","enrollment":7400},{"nctId":"NCT06429930","phase":"PHASE1","title":"Safety, Tolerability and Pharmacokinetics Study of L608 in Healthy Adults","status":"RECRUITING","sponsor":"Pharmosa Biopharm Inc.","startDate":"2025-04-11","conditions":"Pulmonary Arterial Hypertension","enrollment":32},{"nctId":"NCT07013149","phase":"","title":"The Impact of ERA Switching on Risk Stratification in Pulmonary Arterial Hypertension","status":"RECRUITING","sponsor":"University of Sao Paulo General Hospital","startDate":"2025-08-20","conditions":"Pulmonary Arterial Hypertension, Pulmonary Arterial Hypertension (PAH), Pulmonary Arterial Hypertension (PAH) (WHO Group 1 PH)","enrollment":121},{"nctId":"NCT03617458","phase":"PHASE2","title":"Interventions Against Insulin Resistance in Pulmonary Arterial Hypertension","status":"COMPLETED","sponsor":"Vanderbilt University Medical Center","startDate":"2018-08-23","conditions":"Pulmonary Artery Hypertension","enrollment":73},{"nctId":"NCT06980584","phase":"NA","title":"Study on the Treatment of Nonthrombotic Obstructive Pulmonary Hypertension","status":"RECRUITING","sponsor":"Beijing Chao Yang Hospital","startDate":"2025-02-10","conditions":"Fibrosing Mediastinitis, Pulmonary Hypertension","enrollment":48},{"nctId":"NCT03795428","phase":"PHASE2","title":"Long-Term, Open Label Extension Study of Pemziviptadil (PB1046) in PAH Subjects Following Completion of Study PB1046-PT-CL-0004","status":"TERMINATED","sponsor":"PhaseBio Pharmaceuticals Inc.","startDate":"2019-04-10","conditions":"Pulmonary Arterial Hypertension","enrollment":25},{"nctId":"NCT00989963","phase":"PHASE2","title":"Dose-response Study of the Safety and Efficacy of Beraprost Sodium Modified Release (BPS-MR) in Patients With Pulmonary Arterial Hypertension (PAH)","status":"COMPLETED","sponsor":"Lung Biotechnology PBC","startDate":"2010-02-01","conditions":"Pulmonary Arterial Hypertension","enrollment":36},{"nctId":"NCT01548950","phase":"NA","title":"Drug Therapy and Surgery in Congenital Heart Disease With Pulmonary Hypertension","status":"COMPLETED","sponsor":"University of Sao Paulo General Hospital","startDate":"2011-09","conditions":"Congenital Heart Disease, Pulmonary Arterial Hypertension","enrollment":50},{"nctId":"NCT01586156","phase":"NA","title":"PAHTCH Pulmonary Arterial Hypertension Treatment With Carvedilol for Heart Failure (Carvedilol)","status":"COMPLETED","sponsor":"The Cleveland Clinic","startDate":"2012-12","conditions":"Pulmonary Hypertension","enrollment":30},{"nctId":"NCT02576002","phase":"","title":"Epidemiology and Treatment Patterns of Paediatric PAH (Pulmonary Arterial Hypertension)","status":"COMPLETED","sponsor":"Bayer","startDate":"2015-10","conditions":"Hypertension, Pulmonary","enrollment":2691},{"nctId":"NCT01458236","phase":"PHASE3","title":"A Multinational, Multicenter, Study to Assess the Efficacy and Safety of BPS-314d-MR in Subjects With Pulmonary Arterial Hypertension Currently Receiving Treatment With an Endothelin Receptor Antagonist and/or a Phosphodiesterase-5 Inhibitor","status":"WITHDRAWN","sponsor":"Lung Biotechnology PBC","startDate":"2011-11","conditions":"Pulmonary Arterial Hypertension","enrollment":""},{"nctId":"NCT00615823","phase":"PHASE2","title":"Atorvastatin in Pulmonary Hypertension","status":"COMPLETED","sponsor":"Chinese Academy of Medical Sciences, Fuwai Hospital","startDate":"2007-02","conditions":"Hypertension, Pulmonary","enrollment":220}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_2","status":"active","brandName":"Assigned pulmonary hypertension medication","genericName":"Assigned pulmonary hypertension medication","companyName":"Bayer","companyId":"bayer","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This drug works by inhibiting the action of endothelin-1, a potent vasoconstrictor. Used for Treatment of pulmonary arterial hypertension.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}