{"id":"aspoxicillin","rwe":[],"tags":[{"label":"aspoxicillin","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"J01CA19","category":"atc"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{"commonSideEffects":[]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":["aspoxicillin"],"offLabel":[],"synonyms":["aspoxicillin"],"timeline":[],"ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"aspoxicillin","explanation":"Think of the bacterial cell wall like a strong, protective shield. ASPOXICILLIN blocks the production of this shield, making it difficult for the bacteria to maintain its structure and ultimately leading to its demise. This allows the body's immune system to more effectively fight off the infection.","oneSentence":"ASPOXICILLIN works by inhibiting the synthesis of the bacterial cell wall, ultimately leading to cell lysis and death.","technicalDetail":"ASPOXICILLIN exerts its antibacterial effect by binding to penicillin-binding proteins (PBPs) located on the bacterial cell wall, thereby inhibiting the transpeptidation reaction that is essential for cell wall synthesis and ultimately leading to cell lysis."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/248","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=ASPOXICILLIN","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T08:50:29.467637","biosimilars":[],"competitors":[{"drugName":"ampicillin","drugSlug":"ampicillin","fdaApproval":"1965-12-17","genericCount":18,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"carbenicillin","drugSlug":"carbenicillin","fdaApproval":"","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"amoxicillin","drugSlug":"amoxicillin","fdaApproval":"1974-12-09","patentExpiry":"May 7, 2027","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"carindacillin","drugSlug":"carindacillin","fdaApproval":"1972-10-26","relationship":"same-class"},{"drugName":"bacampicillin","drugSlug":"bacampicillin","fdaApproval":"1980-12-22","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"azlocillin","drugSlug":"azlocillin","fdaApproval":"1982-09-03","genericCount":1,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"mezlocillin","drugSlug":"mezlocillin","fdaApproval":"1981-09-21","genericCount":1,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"mecillinam","drugSlug":"mecillinam","fdaApproval":"","relationship":"same-class"},{"drugName":"piperacillin","drugSlug":"piperacillin","fdaApproval":"1981-12-29","genericCount":2,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"ticarcillin","drugSlug":"ticarcillin","fdaApproval":"1976-11-09","genericCount":1,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"hetacillin","drugSlug":"hetacillin","fdaApproval":"","genericCount":1,"patentStatus":"Off-patent — generic available","relationship":"same-class"}],"genericName":"aspoxicillin","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"ampicillin","brandName":"ampicillin","genericName":"ampicillin","approvalYear":"1965","relationship":"same-class"},{"drugId":"carbenicillin","brandName":"carbenicillin","genericName":"carbenicillin","approvalYear":"","relationship":"same-class"},{"drugId":"amoxicillin","brandName":"amoxicillin","genericName":"amoxicillin","approvalYear":"1974","relationship":"same-class"},{"drugId":"carindacillin","brandName":"carindacillin","genericName":"carindacillin","approvalYear":"1972","relationship":"same-class"},{"drugId":"bacampicillin","brandName":"bacampicillin","genericName":"bacampicillin","approvalYear":"1980","relationship":"same-class"},{"drugId":"azlocillin","brandName":"azlocillin","genericName":"azlocillin","approvalYear":"1982","relationship":"same-class"},{"drugId":"mezlocillin","brandName":"mezlocillin","genericName":"mezlocillin","approvalYear":"1981","relationship":"same-class"},{"drugId":"mecillinam","brandName":"mecillinam","genericName":"mecillinam","approvalYear":"","relationship":"same-class"},{"drugId":"piperacillin","brandName":"piperacillin","genericName":"piperacillin","approvalYear":"1981","relationship":"same-class"},{"drugId":"ticarcillin","brandName":"ticarcillin","genericName":"ticarcillin","approvalYear":"1976","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"0745KNO26J","CHEBI":"CHEBI:31240","INN_ID":"5350","UMLSCUI":"C0104449","ChEMBL_ID":"CHEMBL1318150","KEGG_DRUG":"D07469","DRUGBANK_ID":"DB13816","PUBCHEM_CID":"71961","IUPHAR_LIGAND_ID":"12293","MESH_SUPPLEMENTAL_RECORD_UI":"C037485"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"pharmacokinetics":{"source":"DrugCentral","halfLife":"1.45 hours","clearance":"2.82 mL/min/kg","volumeOfDistribution":"0.27 L/kg"},"publicationCount":60,"therapeuticAreas":["Infectious Disease"],"atcClassification":{"source":"DrugCentral","atcCode":"J01CA19","allCodes":["J01CA19"]},"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","brandName":"ASPOXICILLIN","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"ASPOXICILLIN is a small molecule antibiotic drug of the aspoxicillin class. Its mechanism of action involves inhibiting bacterial cell wall synthesis, specifically targeting penicillin-binding proteins. However, due to the lack of available information, its target, approved indications, and commercial status are unknown. Further research is needed to determine its efficacy and safety profile. As a result, it is not possible to provide a comprehensive summary of its clinical use.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}