{"id":"aspirin-and-thienopyridine","safety":{"commonSideEffects":[{"rate":"2-5","effect":"Bleeding (major and minor)"},{"rate":"1-3","effect":"Gastrointestinal bleeding"},{"rate":"5-10","effect":"Dyspepsia"},{"rate":null,"effect":"Bruising"},{"rate":"0.1-0.5","effect":"Neutropenia (thienopyridine-specific)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Aspirin irreversibly inhibits cyclooxygenase (COX), reducing thromboxane A2 production and platelet activation. Thienopyridines (such as clopidogrel or ticlopidine) are P2Y12 adenosine diphosphate receptor antagonists that block platelet aggregation. Together, they provide complementary antiplatelet effects, reducing thrombotic events more effectively than either agent alone.","oneSentence":"Aspirin and thienopyridine work together as dual antiplatelet agents to prevent blood clots by inhibiting platelet aggregation through different pathways.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:27:53.504Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute coronary syndrome (ACS) with percutaneous coronary intervention (PCI)"},{"name":"Secondary prevention of myocardial infarction and stent thrombosis"},{"name":"Stroke prevention in patients with recent ischemic stroke or transient ischemic attack"}]},"trialDetails":[{"nctId":"NCT06757764","phase":"PHASE4","title":"The Effect and Safety of Combined Anti-platelet Treatment in Acute Ischemic Stroke Due to Large Artery Atherosclerosis","status":"RECRUITING","sponsor":"Asan Medical Center","startDate":"2025-07-10","conditions":"Cerebral Infarction, Stenosis Artery","enrollment":2340},{"nctId":"NCT06650488","phase":"PHASE4","title":"Clopidogrel vs. Aspirin for Cardiovascular Risk Reduction in Patients With S. 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