{"id":"aspirin-and-nsaid","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal bleeding or ulceration"},{"rate":null,"effect":"Dyspepsia"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Abdominal pain"}]},"_chembl":{"chemblId":"CHEMBL25","moleculeType":"Small molecule","molecularWeight":"180.16"},"_dailymed":{"setId":"2c8df1c7-7864-48df-939c-d9ae22e0f52c","title":"EXCEDRIN EXTRA STRENGTH AND EXCEDRIN TENSION HEADACHE (ACETAMINOPHEN, ASPIRIN (NSAID), AND CAFFEINE) KIT [HALEON US HOLDINGS LLC]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Aspirin irreversibly inhibits cyclooxygenase (COX) enzymes to block prostaglandin synthesis, providing antiplatelet and anti-inflammatory effects. The addition of an NSAID (specific agent not specified in the designation) provides complementary COX inhibition for enhanced analgesia and anti-inflammation. POZEN's formulation approach aims to optimize the therapeutic benefit-risk profile, though combining two NSAIDs/aspirin typically requires careful GI protection strategies.","oneSentence":"This combination product pairs aspirin with an NSAID to provide anti-inflammatory and analgesic effects while potentially reducing gastrointestinal toxicity through a fixed-dose formulation.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T04:55:31.579Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute pain management"},{"name":"Cardiovascular protection (aspirin component)"}]},"trialDetails":[],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":14644,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"aspirin and [NSAID]","genericName":"aspirin and [NSAID]","companyName":"POZEN","companyId":"pozen","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This combination product pairs aspirin with an NSAID to provide anti-inflammatory and analgesic effects while potentially reducing gastrointestinal toxicity through a fixed-dose formulation. Used for Acute pain management, Cardiovascular protection (aspirin component).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":false,"score":3}}