{"id":"aspirin-acetaminophen-and-caffeine","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal upset"},{"rate":null,"effect":"Heartburn"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Jitteriness or nervousness (caffeine-related)"},{"rate":null,"effect":"Sleep disturbance"}]},"_chembl":null,"_dailymed":{"setId":"0666f082-84f3-4041-a322-311188a15670","title":"HEADACHE RELIEF EXTRA STRENGTH (ACETAMINOPHEN, ASPIRIN AND CAFFEINE) TABLET, FILM COATED [SALADO SALES, INC.]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Aspirin irreversibly inhibits COX-1 and COX-2, reducing prostaglandin synthesis and providing anti-inflammatory and analgesic effects. Acetaminophen's exact mechanism remains incompletely understood but involves inhibition of prostaglandin synthesis and modulation of serotonergic and cannabinoid pathways in the central nervous system. Caffeine acts as a CNS stimulant and potentiates the analgesic effects of both aspirin and acetaminophen, likely through adenosine receptor antagonism.","oneSentence":"This combination analgesic and antipyretic works through multiple pathways: aspirin inhibits cyclooxygenase to reduce prostaglandins, acetaminophen inhibits pain and fever centers in the CNS, and caffeine enhances analgesic efficacy while promoting alertness.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:26:47.933Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Mild to moderate pain (headache, muscle ache, backache, minor arthritis pain, menstrual cramps, common cold)"},{"name":"Fever"}]},"trialDetails":[{"nctId":"NCT07022496","phase":"PHASE4","title":"Assessment of Oral Caffeine Intake in Changing the Severity of Acute Migraine Attack Using VAS Score Among Patients Attending Headache and Neurology Outpatients Clinic of Ainshams University Hospitals","status":"RECRUITING","sponsor":"Ain Shams University","startDate":"2023-04-26","conditions":"Migraine, Migraine Disease, Migraine Headache","enrollment":120},{"nctId":"NCT01264965","phase":"PHASE4","title":"Non-cancer Pain and Cognitive Impairment: A Disabling Relationship","status":"TERMINATED","sponsor":"University of Chicago","startDate":"2011-01","conditions":"Arthritis, Pain, Cognitive Impairment","enrollment":25},{"nctId":"NCT01629329","phase":"PHASE4","title":"Prochlorperazine Versus Acetaminophen, Aspirin, and Caffeine for the Treatment of Acute Migraine","status":"TERMINATED","sponsor":"Albert Einstein Healthcare Network","startDate":"2010-11","conditions":"Migraine Headaches","enrollment":93},{"nctId":"NCT02183688","phase":"PHASE3","title":"Acetylsalicylic Acid (ASA) + Paracetamol + Caffeine Combination Compared With ASA + Paracetamol as Well as ASA, Paracetamol, and Caffeine in Headache Patients","status":"COMPLETED","sponsor":"Boehringer Ingelheim","startDate":"1998-09","conditions":"Migraine Disorders","enrollment":1889},{"nctId":"NCT01248468","phase":"PHASE4","title":"Efficacy and Safety of Acetaminophen, Aspirin and Caffeine With Sumatriptan in the Acute Treatment of Migraine","status":"COMPLETED","sponsor":"Novartis","startDate":"2010-11","conditions":"Pain, Migraine","enrollment":752}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Aspirin, acetaminophen and caffeine","genericName":"Aspirin, acetaminophen and caffeine","companyName":"Novartis","companyId":"novartis","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This combination analgesic and antipyretic works through multiple pathways: aspirin inhibits cyclooxygenase to reduce prostaglandins, acetaminophen inhibits pain and fever centers in the CNS, and caffeine enhances analgesic efficacy while promoting alertness. Used for Mild to moderate pain (headache, muscle ache, backache, minor arthritis pain, menstrual cramps, common cold), Fever.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}