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Keep out of reach of children. In case of overdose, contact a physician or Poison Control Center right away. Tamper Evident: Sealed for your protection. Do not use if seal is broken or missing."],"questions":["QUESTIONS: Dist. By: Deseret Biologicals, Inc. 469 W. Parkland Drive Sandy, UT 84070 www.desbio.com 800-827-8204"],"effective_time":"20250311","active_ingredient":["ACTIVE INGREDIENTS: Arsenicum Album 12X, Aspartame 30X, Benzalkonium Chloride 30X, Beta Vulgaris 3X, Bisphenol A 12X, Boldo 3X, Chelidonium Majus 3X, Cobaltum Metallicum 12X, Cuprum Metallicum 12X, Formalinum 30X, Glyphosate 12X, Iodium 12X, Lycopodium Clavatum 12X, Methylene Chloride 30X, Methylparaben 30X, Petroselinum Sativum 3X, Phosphoricum Acidum 12X, Propylparaben 30X, Selenium Metallicum 12X, Sodium Benzoate 30X, Sodium Citrate 30X, Taraxacum Officinale 3X, Titanium Dioxide 30X, Zincum Metallicum 12X, Zincum Oxydatum 30X."],"inactive_ingredient":["INACTIVE INGREDIENTS: Demineralized water, 25% ethanol"],"indications_and_usage":["USES: • For the temporary relief of symptoms including: • headache • liver support • muscle weakness • skin irritation • poor muscle coordination These statements are based upon homeopathic principles. They have not been reviewed by the Food and Drug Administration."],"dosage_and_administration":["DIRECTIONS: 1-10 drops under the tongue, 3 times a day or as directed by a health professional. Consult a physician for use in children under 12 years of age."],"spl_product_data_elements":["Addiclenz Aspartame, Benzalkonium Chloride, Formalinum, Methylene Chloride, Methylparaben, Propylparaben, Sodium Benzoate, Sodium Citrate, Titanium Dioxide, Zincum Oxydatum, Arsenicum Album, Beta Vulgaris, Bisphenol A, Boldo, Chelidonium Majus, Cobaltum Metallicum, Cuprum Metallicum, Glyphosate, Iodium, Lycopodium Clavatum, Petroselinum Sativum, Phosphoricum Acidum, Selenium Metallicum, Taraxacum Officinale, Zincum Metallicum ASPARTAME ASPARTAME BENZALKONIUM CHLORIDE BENZALKONIUM FORMALDEHYDE SOLUTION FORMALDEHYDE SOLUTION METHYLENE CHLORIDE METHYLENE CHLORIDE METHYLPARABEN METHYLPARABEN PROPYLPARABEN PROPYLPARABEN SODIUM BENZOATE BENZOIC ACID SODIUM CITRATE, UNSPECIFIED FORM ANHYDROUS CITRIC ACID TITANIUM DIOXIDE TITANIUM DIOXIDE ZINC OXIDE ZINC CATION ARSENIC TRIOXIDE ARSENIC CATION (3+) BETA VULGARIS WHOLE BETA VULGARIS BISPHENOL A BISPHENOL A PEUMUS BOLDUS LEAF PEUMUS BOLDUS LEAF CHELIDONIUM MAJUS WHOLE CHELIDONIUM MAJUS COBALT COBALT COPPER BRONZE POWDER GLYPHOSATE GLYPHOSATE IODINE IODINE LYCOPODIUM CLAVATUM SPORE LYCOPODIUM CLAVATUM SPORE PETROSELINUM CRISPUM WHOLE PETROSELINUM CRISPUM PHOSPHORIC ACID PHOSPHORIC ACID SELENIUM SELENIUM TARAXACUM OFFICINALE TARAXACUM OFFICINALE ZINC ZINC WATER ALCOHOL"],"keep_out_of_reach_of_children":["KEEP OUT OF REACH OF CHILDREN: In case of overdose, contact a physician or Poison Control Center right away."],"package_label_principal_display_panel":["PACKAGE LABEL DISPLAY: DesBio Addiclenz Homeopathic NDC 43742-2261-1 1 FL OZ (30 ml) Addiclenz"]},"tags":[{"label":"Standardized Chemical Allergen [EPC]","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Oral","category":"route"},{"label":"Active","category":"status"},{"label":"headache","category":"indication"},{"label":"liver support","category":"indication"},{"label":"muscle weakness","category":"indication"},{"label":"skin irritation","category":"indication"},{"label":"poor muscle coordination","category":"indication"},{"label":"Deseret Biologicals, Inc.","category":"company"}],"phase":"marketed","safety":{"boxedWarnings":[]},"trials":[],"aliases":[],"company":"Deseret Biologicals, Inc.","patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=ASPARTAME","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T00:07:42.403195+00:00"},"timeline":{"url":"https://en.wikipedia.org/wiki/Aspartame","method":"deterministic","source":"Wikipedia","rawText":"","confidence":0.8,"sourceType":"wikipedia","retrievedAt":"2026-04-20T00:07:54.840867+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T00:07:53.618342+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=ASPARTAME","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T00:07:54.288752+00:00"},"mechanism.drugClass":{"url":"https://api.fda.gov/drug/label.json","method":"deterministic","source":"FDA Label (EPC)","rawText":"","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T00:07:40.178373+00:00"},"administration.route":{"url":"","method":"deterministic","source":"FDA Label","rawText":"","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T00:07:40.178435+00:00"},"safety.boxedWarnings":{"url":"","method":"deterministic","source":"FDA Label (no boxed warning)","rawText":"","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T00:07:40.178452+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL171679/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T00:07:54.751736+00:00"}},"allNames":"addiclenz","offLabel":[],"synonyms":["Addiclenz","ARSENIC TRIOXIDE"],"timeline":[],"approvals":[],"brandName":"Addiclenz","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"Standardized Chemical Allergen [EPC]","explanation":"","oneSentence":"","technicalDetail":"Aspartame is a methyl ester of aspartic acid and phenylalanine, which is metabolized into phenylalanine and aspartic acid. The exact mechanism of its allergenic effects is not fully understood, but it is thought to involve the activation of T-cells and the release of histamine and other chemical mediators."},"_wikipedia":{"url":"https://en.wikipedia.org/wiki/Aspartame","title":"Aspartame","extract":"Aspartame is an artificial, non-saccharide sweetener commonly used as a sugar substitute in foods and beverages. It is 200 times sweeter than sucrose, and is a methyl ester of the aspartic acid/phenylalanine dipeptide with brand names NutraSweet, Equal, and Canderel. Discovered in 1965, aspartame was approved by the US Food and Drug Administration (FDA) in 1974 and re-approved in 1981 after its initial approval was briefly revoked.","wiki_history":"==History==\n\nAspartame was discovered by accident by James M. Schlatter, a chemist working for G.D. Searle & Company in Skokie, Illinois. Schlatter had synthesized aspartame as an intermediate step in generating a tetrapeptide of the hormone gastrin, for use in assessing an anti-ulcer drug candidate. He discovered its sweet taste when he licked his finger, which had become contaminated with aspartame, to lift up a piece of paper. Torunn Atteraas Garin participated in the development of aspartame as an artificial sweetener.\n\nIn 1975, prompted by issues regarding Flagyl and Aldactone, an FDA task force team reviewed 25 studies submitted by the manufacturer, including 11 on aspartame. The team reported \"serious deficiencies in Searle's operations and practices\". The FDA sought to authenticate 15 of the submitted studies against the supporting data. In 1979, the Center for Food Safety and Applied Nutrition (CFSAN) concluded, since many problems with the aspartame studies were minor and did not affect the conclusions, the studies could be used to assess aspartame's safety.\n\nIn 1983, the FDA approved aspartame for use in carbonated beverages and for use in other beverages, baked goods, and confections in 1993. As of May 2023, the FDA stated that it regards aspartame as a safe food ingredient when consumed within the acceptable daily intake level of 50 mg per kg of body weight per day.\n\n===Compendial status===\n* British Pharmacopoeia\n* United States Pharmacopeia"},"commercial":{},"references":[{"id":1,"url":"https://api.fda.gov/drug/label.json?search=openfda.generic_name:\"ASPARTAME\"","fields":["mechanism","indications","adverse_reactions","contraindications","warnings","dosage"],"source":"OpenFDA 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