{"id":"ascorbic-acid-vitamin-b1-hydrocortisone","safety":{"commonSideEffects":[{"rate":null,"effect":"Hyperglycemia"},{"rate":null,"effect":"Immunosuppression"},{"rate":null,"effect":"Gastrointestinal upset"},{"rate":null,"effect":"Insomnia or mood changes"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Hydrocortisone suppresses inflammatory and immune responses by binding glucocorticoid receptors. Ascorbic acid (vitamin C) acts as an antioxidant and cofactor for collagen synthesis and immune function. Vitamin B1 (thiamine) serves as a coenzyme in carbohydrate and energy metabolism. Together, these agents provide symptomatic relief and support recovery in conditions involving inflammation, oxidative stress, and metabolic demand.","oneSentence":"This combination provides anti-inflammatory, immune support, and antioxidant effects through hydrocortisone's glucocorticoid action, vitamin B1's cofactor role in metabolism, and ascorbic acid's antioxidant properties.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T00:27:48.136Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Nutritional supplementation and anti-inflammatory support in hospitalized or acutely ill patients"},{"name":"Adjunctive therapy for conditions requiring corticosteroid and micronutrient support"}]},"trialDetails":[{"nctId":"NCT04921189","phase":"PHASE2","title":"Steroid, Thiamine and Ascorbic Acid for Comatose Out-of-hospital Cardiac Arrest Survivors","status":"COMPLETED","sponsor":"Asan Medical Center","startDate":"2021-12-31","conditions":"Out-Of-Hospital Cardiac Arrest, Postcardiac Arrest Syndrome","enrollment":160},{"nctId":"NCT06723626","phase":"NA","title":"Effects of Intravenous Metabolic Recovery Agent in Elderly Septic Patients on Prognosis and Microcirculation.","status":"RECRUITING","sponsor":"Southeast University, China","startDate":"2024-07-01","conditions":"Septic Shock","enrollment":40},{"nctId":"NCT03649633","phase":"PHASE1, PHASE2","title":"Vitamin C, Steroids, and Thiamine, and Cerebral Autoregulation and Functional Outcome in Septic Shock","status":"TERMINATED","sponsor":"University of Athens","startDate":"2018-09-06","conditions":"Septic Shock","enrollment":26},{"nctId":"NCT03592693","phase":"PHASE2","title":"Vitamin C, Hydrocortisone and Thiamine for Septic Shock","status":"TERMINATED","sponsor":"University of Athens","startDate":"2018-09-06","conditions":"Shock, Septic","enrollment":24},{"nctId":"NCT03540628","phase":"NA","title":"Thiamine, Vitamin C and Hydrocortisone in the Treatment of Septic Shock","status":"COMPLETED","sponsor":"Corewell Health South","startDate":"2018-02-26","conditions":"Septic Shock","enrollment":17},{"nctId":"NCT05157360","phase":"PHASE1, PHASE2","title":"HAT for the Treatment of Sepsis Associated With NASTI","status":"TERMINATED","sponsor":"Ascension Via Christi Hospitals Wichita, Inc.","startDate":"2021-09-10","conditions":"Necrotizing Soft Tissue Infection, Sepsis","enrollment":10},{"nctId":"NCT05192213","phase":"PHASE3","title":"Vitamin C, Hydrocortisone and Thiamine in Patients With Septic Shock","status":"TERMINATED","sponsor":"Hospital Sirio-Libanes","startDate":"2021-08-01","conditions":"Sepsis, Septic Shock","enrollment":71},{"nctId":"NCT06152458","phase":"PHASE4","title":"Blessing or Curse? Combined Vitamin Therapy in Non Viral Septic Shock.","status":"COMPLETED","sponsor":"University of Pecs","startDate":"2019-01-01","conditions":"Septic Shock","enrollment":43},{"nctId":"NCT03821714","phase":"NA","title":"Effects of Glucocorticoid Combined With Vitamin C and Vitamin B1 on Microcirculation in Severe Septic Shock","status":"COMPLETED","sponsor":"Southeast University, China","startDate":"2019-02-01","conditions":"Septic Shock","enrollment":22},{"nctId":"NCT04111822","phase":"PHASE3","title":"Pilot Study on the Use of Hydrocortisone, Vitamin c and Tiamine in Patient With Sepsis and Septic Shock","status":"COMPLETED","sponsor":"Cristina Martinez","startDate":"2018-10-31","conditions":"Sepsis, Septic Shock","enrollment":40},{"nctId":"NCT03380507","phase":"PHASE2, PHASE3","title":"Evaluation of Hydrocortisone, Vitamin C and Thiamine for the Treatment of Septic Shock","status":"TERMINATED","sponsor":"Hamad Medical Corporation","startDate":"2018-03-17","conditions":"Septic Shock, Critical Illness","enrollment":106},{"nctId":"NCT03872011","phase":"PHASE3","title":"Vitamin C, Thiamine and Hydrocortisone for the Treatment of Septic Shock","status":"COMPLETED","sponsor":"Northern Jiangsu People's Hospital","startDate":"2019-02-19","conditions":"Septic Shock","enrollment":408},{"nctId":"NCT03422159","phase":"PHASE2","title":"Metabolic Resuscitation Using Ascorbic Acid, Thiamine, and Glucocorticoids in Sepsis.","status":"COMPLETED","sponsor":"Community Medical Center, Toms River, NJ","startDate":"2018-02-05","conditions":"Sepsis, Severe, Septic Shock","enrollment":140},{"nctId":"NCT03913468","phase":"","title":"Outcomes of Septic Shock Patients Treated With a Metabolic Resuscitation Bundle Consisting of Intravenous Hydrocortisone, Ascorbic Acid and Thiamine.","status":"COMPLETED","sponsor":"University of Wisconsin, Madison","startDate":"2019-01-01","conditions":"Septic Shock, Ascorbic Acid Deficiency","enrollment":206},{"nctId":"NCT04160676","phase":"NA","title":"Therapy With Hydrocortisone, Ascorbic Acid, Thamine in Patients With Sepsis","status":"COMPLETED","sponsor":"Tanta University","startDate":"2019-12-01","conditions":"Sepsis","enrollment":80},{"nctId":"NCT03509350","phase":"PHASE3","title":"Vitamin C, Thiamine, and Steroids in Sepsis","status":"COMPLETED","sponsor":"Emory University","startDate":"2018-08-22","conditions":"Sepsis","enrollment":501},{"nctId":"NCT03389555","phase":"PHASE2, PHASE3","title":"Ascorbic Acid, Corticosteroids, and Thiamine in Sepsis (ACTS) Trial","status":"COMPLETED","sponsor":"Beth Israel Deaconess Medical Center","startDate":"2018-02-09","conditions":"Sepsis, Septic Shock, Metabolic Disturbance","enrollment":205},{"nctId":"NCT04508946","phase":"PHASE3","title":"Triple Therapy in Septic Shock Patients","status":"COMPLETED","sponsor":"Air Force Specialized Hospital, Cairo, Egypt","startDate":"2019-08-01","conditions":"Septic Shock, Sepsis, Organ Dysfunction Syndrome Sepsis","enrollment":94},{"nctId":"NCT04197115","phase":"PHASE3","title":"Vitamin C, Thiamine, Cyanocobalamine, Pyridoxine and Hydrocortisone in Sepsis","status":"COMPLETED","sponsor":"IMSS Hospital General de Zona 11, Piedras Negras","startDate":"2019-09-01","conditions":"Sepsis, Septic Shock","enrollment":19},{"nctId":"NCT04039815","phase":"PHASE4","title":"Vitamin C, Vitamin B1 and Steroid in Sepsis","status":"UNKNOWN","sponsor":"Far Eastern Memorial Hospital","startDate":"2019-12-03","conditions":"Sepsis, Severe","enrollment":80},{"nctId":"NCT04134403","phase":"PHASE3","title":"Steroids, Thiamine and Ascorbic Acid in Septic Shock","status":"UNKNOWN","sponsor":"Baqiyatallah Medical Sciences University","startDate":"2019-12-01","conditions":"Septic Shock","enrollment":80},{"nctId":"NCT03333278","phase":"PHASE2","title":"The Vitamin C, Hydrocortisone and Thiamine in Patients With Septic Shock Trial","status":"COMPLETED","sponsor":"Australian and New Zealand Intensive Care Research Centre","startDate":"2018-05-02","conditions":"Shock, Septic, Critically Ill, Vasoplegic Syndrome","enrollment":216},{"nctId":"NCT03258684","phase":"NA","title":"Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Sepsis and Septic Shock","status":"COMPLETED","sponsor":"Zhujiang Hospital","startDate":"2017-09-25","conditions":"Sepsis","enrollment":80},{"nctId":"NCT03335124","phase":"PHASE4","title":"The Effect of Vitamin C, Thiamine and Hydrocortisone on Clinical Course and Outcome in Patients With Severe Sepsis and Septic Shock","status":"TERMINATED","sponsor":"University Medical Centre Ljubljana","startDate":"2017-09-26","conditions":"Sepsis, Septic Shock, Critical Illness","enrollment":5}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Ascorbic acid-Vitamin B1-Hydrocortisone","genericName":"Ascorbic acid-Vitamin B1-Hydrocortisone","companyName":"Far Eastern Memorial Hospital","companyId":"far-eastern-memorial-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This combination provides anti-inflammatory, immune support, and antioxidant effects through hydrocortisone's glucocorticoid action, vitamin B1's cofactor role in metabolism, and ascorbic acid's antioxidant properties. Used for Nutritional supplementation and anti-inflammatory support in hospitalized or acutely ill patients, Adjunctive therapy for conditions requiring corticosteroid and micronutrient support.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}