{"id":"asc-secretome","_chembl":{"chemblId":"CHEMBL1778796","moleculeType":"Small molecule","molecularWeight":"757.00"},"modality":"Biologic","_dailymed":null,"mechanism":{"explanation":"ASC secretome contains multiple paracrine factors including growth factors, cytokines, chemokines, and extracellular vesicles that are naturally secreted by adipose-derived stem cells. These factors work collectively to promote tissue regeneration, angiogenesis, and immunomodulation without requiring cell transplantation.","oneSentence":"Delivers a complex mixture of bioactive factors secreted by adipose stem cells to promote tissue repair and modulate inflammation."},"_scrapedAt":"2026-03-28T04:10:55.886Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"_claudeStub":{"ts":1779123618,"model":"claude-sonnet-4-5-20250929"},"description":"ASC secretome is an investigational cell-free biological therapy derived from adipose-derived stem cells (ASCs). It contains a mixture of growth factors, cytokines, and extracellular vesicles secreted by ASCs, being developed by I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio for potential regenerative medicine applications.","indications":{"approved":[{"status":"investigational","condition":"Unknown","patientPopulation":null}]},"trialDetails":[{"nctId":"NCT06684379","phase":"PHASE1, PHASE2","title":"Study on Safety and Efficacy of Two Doses of PRS CK STORM in the Modulation of the Cytokine Storm for the Treatment of Acute Respiratory Distress Syndrome (ARDS) Caused by SARS-Cov-2, Influenza A, Influenza B and Respiratory Syncytial Virus (RSV)","status":"RECRUITING","sponsor":"PEACHES BIOTECH","startDate":"2024-10-02","conditions":"SARS-CoV-2, Influenza, Human, Respiratory Syncytial Virus Infections","enrollment":50},{"nctId":"NCT04223622","phase":"","title":"Effects of ASC Secretome on Human Osteochondral Explants","status":"COMPLETED","sponsor":"I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio","startDate":"2021-04-12","conditions":"Osteoarthritis","enrollment":36}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":55,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_2","status":"active","brandName":"ASC secretome","genericName":"ASC secretome","companyName":"I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio","companyId":"i-r-c-c-s-ospedale-galeazzi-sant-ambrogio","firstApprovalDate":"","aiSummary":"","enrichmentLevel":1,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":true,"score":3}}