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Evening dosing may optimize circadian effects on platelet function and thrombotic risk.","oneSentence":"Aspirin inhibits platelet aggregation by irreversibly acetylating cyclooxygenase (COX) enzymes, reducing thromboxane A2 production.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:02:39.069Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Secondary prevention of cardiovascular events (myocardial infarction, stroke, transient ischemic attack)"},{"name":"Primary prevention of cardiovascular disease in high-risk patients"}]},"trialDetails":[{"nctId":"NCT05761015","phase":"PHASE4","title":"Helping Osteoarthritis Patients to Walk With NSAID","status":"RECRUITING","sponsor":"University Hospital, Clermont-Ferrand","startDate":"2023-12-14","conditions":"Osteoarthritis, Knee, Osteoarthritis, Hip, Chronic Pain","enrollment":55},{"nctId":"NCT03907046","phase":"PHASE3","title":"Anticoagulation in ICH Survivors for Stroke Prevention and 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