{"id":"as-guilin-pharmaceuticals","safety":{"commonSideEffects":[{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Vomiting"},{"rate":null,"effect":"Diarrhea"},{"rate":null,"effect":"Abdominal pain"},{"rate":null,"effect":"Headache"}]},"_chembl":{"chemblId":"CHEMBL1231533","moleculeType":"Small molecule","molecularWeight":"285.23"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Artemisinin derivatives work by being activated in the presence of heme iron from the malaria parasite, generating free radicals that damage parasite proteins and membranes. This mechanism is particularly effective against Plasmodium species and has been a cornerstone of malaria treatment, especially in artemisinin combination therapies (ACTs).","oneSentence":"AS is an artemisinin-based antimalarial compound that generates reactive oxygen species to kill malaria parasites.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:02:35.986Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Malaria (Plasmodium falciparum and other species)"}]},"trialDetails":[{"nctId":"NCT07246525","phase":"PHASE4","title":"Intermittent Preventive Treatment of Malaria in School-age Children to Decrease Community Transmission","status":"NOT_YET_RECRUITING","sponsor":"University of California, San Francisco","startDate":"2026-05-01","conditions":"Malaria","enrollment":4800},{"nctId":"NCT06173206","phase":"PHASE3","title":"Parasite Clearance and Protection from Infection (PCPI) in Cameroon","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2024-06-10","conditions":"Malaria","enrollment":902},{"nctId":"NCT06166498","phase":"PHASE3","title":"Parasite Clearance and Protection From Infection (PCPI) in Zambia","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2024-07-24","conditions":"Malaria","enrollment":600},{"nctId":"NCT04844099","phase":"PHASE3","title":"Dihydroartemisinin-Piperaquine or Sulphadoxine-Pyrimethamine for the Chemoprevention of Malaria in Sickle Cell Anaemia","status":"COMPLETED","sponsor":"Liverpool School of Tropical Medicine","startDate":"2021-04-09","conditions":"Sickle Cell Anemia in Children, Malaria","enrollment":723},{"nctId":"NCT01640587","phase":"NA","title":"Compare the Effectiveness Between Existing Treatment and New Treatment","status":"TERMINATED","sponsor":"University of Oxford","startDate":"2013-11","conditions":"P. Falciparum Malaria","enrollment":76},{"nctId":"NCT01707199","phase":"NA","title":"SPK Study in Afghanistan","status":"COMPLETED","sponsor":"University of Oxford","startDate":"2012-10","conditions":"Uncomplicated P. Falciparum Malaria","enrollment":83},{"nctId":"NCT03083769","phase":"","title":"Functional Genetic Variants Affecting Tacrolimus Trough Levels and Side Effects in Chinese Renal Transplantation.","status":"COMPLETED","sponsor":"Southern Medical University, China","startDate":"1998-01-01","conditions":"Transplantation","enrollment":1502},{"nctId":"NCT02955771","phase":"PHASE2","title":"Efficacy and Safety Study of PDT Using Deuteporfin for Unresectable Advanced Perihilar Cholangiocarcinoma","status":"TERMINATED","sponsor":"Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd.","startDate":"2017-05-17","conditions":"Hilar Cholangiocarcinoma","enrollment":7},{"nctId":"NCT01955382","phase":"PHASE2","title":"Evaluation of Oral Activated Charcoal on Antimalarial Drug's Ability to Kill Parasites in Malian Children With Malaria","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"2013-09","conditions":"Malaria, Severe Malaria","enrollment":70},{"nctId":"NCT02874963","phase":"NA","title":"FM-SRP and Tooth Extraction Improve Type 2 Diabetes Mellitus in Periodontitis","status":"UNKNOWN","sponsor":"University Clinical Centre of Kosova","startDate":"2015-11","conditions":"Periodontitis, Type 2 Diabetes Mellitus","enrollment":160},{"nctId":"NCT00393679","phase":"PHASE3","title":"Evaluation of 4 Artemisinin-based Combinations for Treating Uncomplicated Malaria in African Children","status":"COMPLETED","sponsor":"Institute of Tropical Medicine, Belgium","startDate":"2007-07","conditions":"Fever, Malaria","enrollment":4112},{"nctId":"NCT01392014","phase":"PHASE4","title":"Dihydroartemisinin-piperaquine and Primaquine for Uncomplicated Plasmodium Falciparum Cases","status":"COMPLETED","sponsor":"Indonesia University","startDate":"2008-12","conditions":"Malaria","enrollment":374}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":27,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Artesunate"],"phase":"phase_3","status":"active","brandName":"AS (Guilin Pharmaceuticals)","genericName":"AS (Guilin Pharmaceuticals)","companyName":"London School of Hygiene and Tropical Medicine","companyId":"london-school-of-hygiene-and-tropical-medicine","modality":"Small molecule","firstApprovalDate":"","aiSummary":"AS is an artemisinin-based antimalarial compound that generates reactive oxygen species to kill malaria parasites. Used for Malaria (Plasmodium falciparum and other species).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}