{"id":"artificial-tears-eye-drops","_chembl":null,"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=Artificial tears eye-drops","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T05:29:44.639120+00:00"},"aiSummary":{"url":"","method":"ai_extraction","source":"AI Strategic Summary","aiModel":"featherless","rawText":"","confidence":0.9,"sourceType":"ai_extraction","retrievedAt":"2026-04-20T05:29:59.692004+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T05:29:49.673400+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=Artificial tears eye-drops","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T05:29:50.065814+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL5940488/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T05:29:51.219164+00:00"}},"_dailymed":null,"aiSummary":"Artificial tears eye-drops, marketed by Hotel Dieu de France Hospital, hold a position in the over-the-counter ophthalmic market. The key composition patent is set to expire in 2028, providing a period of exclusivity that supports current market presence. The primary risk is the potential increase in competition following the patent expiry in 2028.","_scrapedAt":"2026-03-27T23:42:44.442Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"_validation":{"fieldsValidated":1,"lastValidatedAt":"2026-04-20T05:29:59.692064+00:00","fieldsConflicting":0,"overallConfidence":0.95},"trialDetails":[{"nctId":"NCT07495852","phase":"PHASE3","title":"Phase 3 Trial to Evaluate the Safety and Efficacy of the Second Generation Travoprost Intracameral Implant","status":"RECRUITING","sponsor":"Glaukos Corporation","startDate":"2026-02-17","conditions":"Glaucoma","enrollment":510},{"nctId":"NCT07243275","phase":"PHASE4","title":"SYSTANE® PRO vs. MIEBO™ in Dry Eye Disease","status":"RECRUITING","sponsor":"Indiana University","startDate":"2026-02-18","conditions":"Dry Eye Disease (DED)","enrollment":260},{"nctId":"NCT06544694","phase":"PHASE3","title":"A Study to Investigate the Effect of 0.003% AR-15512 on Subjects With Dry Eye Disease","status":"COMPLETED","sponsor":"Alcon Research","startDate":"2024-10-08","conditions":"Dry Eye Disease","enrollment":80},{"nctId":"NCT06365853","phase":"PHASE2","title":"A Study of Ocular Toxicity Evaluation and Mitigation During Treatment With Mirvetuximab Soravtansine in Participants With Recurrent Ovarian Cancer With High Folate Receptor-Alpha Expression","status":"RECRUITING","sponsor":"AbbVie","startDate":"2024-07-29","conditions":"Recurrent Ovarian Cancer, Folate Receptor-Alpha Positive","enrollment":100},{"nctId":"NCT04149210","phase":"PHASE3","title":"FLuorometholone as Adjunctive MEdical Therapy for TT Surgery (FLAME) Trial","status":"COMPLETED","sponsor":"Massachusetts Eye and Ear Infirmary","startDate":"2021-08-19","conditions":"Trachomatous Trichiasis (TT), Eye Diseases, Eyelid Diseases","enrollment":2410},{"nctId":"NCT05319730","phase":"PHASE1, PHASE2","title":"A Study to Evaluate Investigational Agents With or Without Pembrolizumab (MK-3475) in Participants With Advanced Esophageal Cancer Previously Exposed to Programmed Cell Death 1 Protein (PD-1)/ Programmed Cell Death Ligand 1 (PD-L1) Treatment (MK-3475-06B)","status":"RECRUITING","sponsor":"Merck Sharp & Dohme LLC","startDate":"2023-05-16","conditions":"Esophageal Squamous Cell Carcinoma","enrollment":230},{"nctId":"NCT06089317","phase":"NA","title":"Traditional Chinese Medicine Ultrasonic Atomization Treatment for Dry Eye Disease","status":"COMPLETED","sponsor":"Chinese University of Hong Kong","startDate":"2024-07-28","conditions":"Dry Eye Syndromes","enrollment":200},{"nctId":"NCT05577910","phase":"NA","title":"Vectored Thermal Pulsation, Intense Pulsed Light, and Eyelid Warm Compress Therapies for MGD","status":"COMPLETED","sponsor":"Chinese University of Hong Kong","startDate":"2022-10-08","conditions":"Meibomian Gland Dysfunction","enrollment":374},{"nctId":"NCT06819046","phase":"","title":"Improved Efficacy of Selective Laser Trabeculoplasty With the Addition of Rocklatan Post-treatment vs Artificial Tears Post-treatment","status":"COMPLETED","sponsor":"Colorado Ophthalmology Associates PC","startDate":"2025-02-14","conditions":"Glaucoma","enrollment":70},{"nctId":"NCT06660290","phase":"PHASE3","title":"A Study to Evaluate 0.003% AR-15512 Safety and Drop Attributes","status":"COMPLETED","sponsor":"Alcon Research","startDate":"2025-01-15","conditions":"Dry Eye Disease","enrollment":55},{"nctId":"NCT06792903","phase":"EARLY_PHASE1","title":"YM-101 Eye Drops in the Treatment of Dry Eye Syndrome","status":"COMPLETED","sponsor":"Eye & ENT Hospital of Fudan University","startDate":"2024-04-23","conditions":"Dry Eye","enrollment":30},{"nctId":"NCT07224529","phase":"PHASE4","title":"Efficacy of Vevye Ophthalmic Solution for the Treatment of Meibomian Gland Dysfunction","status":"NOT_YET_RECRUITING","sponsor":"University of Alabama at Birmingham","startDate":"2026-04-01","conditions":"Meibomian Gland Dysfunction (MGD)","enrollment":48},{"nctId":"NCT07284381","phase":"PHASE3","title":"A Clinical Study to Evaluate the Effect and Side Effect of a New Artificial Tear Formulation (ABBV-444) Compared to Refresh Optive Unit Dose in Adult Participants With Dry Eye Disease","status":"RECRUITING","sponsor":"AbbVie","startDate":"2025-12-15","conditions":"Dry Eye Disease","enrollment":250},{"nctId":"NCT07469865","phase":"NA","title":"Efficacy and Safety of 20% and 100% Autologous Serum Eye Drops in Patients With Severe Dry Eye Disease (AST)","status":"COMPLETED","sponsor":"University Hospital, Ghent","startDate":"2021-11-30","conditions":"Dry Eye Disease","enrollment":46},{"nctId":"NCT07463950","phase":"PHASE4","title":"A Non-interventional Study to Evaluate the Anti-inflammatory Effects and the Clinical Efficacy of Topical Water Free Cyclosporin 0.1% Eye Drops in Patients With Dry Eye Disease and Associated Ocular Surface Inflammation Non-responding to Artificial Tears: the FOCUS Study","status":"RECRUITING","sponsor":"Medical University of Vienna","startDate":"2026-01-20","conditions":"Dry Eye Disease (DED)","enrollment":25},{"nctId":"NCT05692739","phase":"PHASE4","title":"Clinical Trial To Determine The Effectiveness And Safety Of Topical Insulin In Dry Eye","status":"COMPLETED","sponsor":"Barbara Burgos Blasco","startDate":"2022-10-19","conditions":"Dry Eye, Insulin","enrollment":116},{"nctId":"NCT07075718","phase":"PHASE2, PHASE3","title":"Phase 2/Phase 3 Trial to Evaluate the Safety and Efficacy of the Second Generation Travoprost Intracameral Implant","status":"RECRUITING","sponsor":"Glaukos Corporation","startDate":"2025-06-12","conditions":"Glaucoma","enrollment":610},{"nctId":"NCT06637423","phase":"PHASE1, PHASE2","title":"A Clinical Study of Sacituzumab Tirumotecan (MK-2870) in Patients With Bladder Cancer (MK-2870-027)","status":"RECRUITING","sponsor":"Merck Sharp & Dohme LLC","startDate":"2024-12-20","conditions":"Non-Muscle Invasive Bladder Cancer","enrollment":32},{"nctId":"NCT07422259","phase":"NA","title":"Tolerability and Efficacy Study of Reinnerva/Lubristil+G vs Vismed","status":"COMPLETED","sponsor":"Medivis SRL","startDate":"2025-06-09","conditions":"Keratoconjunctivitis Sicca","enrollment":40},{"nctId":"NCT07264517","phase":"PHASE2","title":"Evaluating the Safety, Tolerability, and Efficacy of GRF312 5% in Participants With Dry Eye Disease (DED).","status":"RECRUITING","sponsor":"Instituto Grifols, S.A.","startDate":"2025-11-03","conditions":"Dry Eye Disease","enrollment":100},{"nctId":"NCT06859476","phase":"PHASE4","title":"Evaluation of Manzanilla® and Meticel Ofteno® 0.5% for Providing a Relief Sensation to the Eyes","status":"COMPLETED","sponsor":"Laboratorios Sophia S.A de C.V.","startDate":"2025-05-23","conditions":"Ophthalmological Agent Toxicity","enrollment":168},{"nctId":"NCT07382453","phase":"PHASE2","title":"Effect of PAE Hydrogel Loaded With tRF-ASO-Exo on Patients With Diabetic Ocular Surface Diseases","status":"NOT_YET_RECRUITING","sponsor":"Affiliated Hospital of Nantong University","startDate":"2026-02-15","conditions":"Diabetic Keratopathy","enrollment":30},{"nctId":"NCT06213649","phase":"PHASE3","title":"Parasitic Ulcer Treatment Trial","status":"RECRUITING","sponsor":"Jeremy Keenan, MD, MPH","startDate":"2024-07-01","conditions":"Acanthamoeba Keratitis","enrollment":232},{"nctId":"NCT06366087","phase":"PHASE1","title":"Sublingual Atropine Bioequivalence by Route of Administration (SABER)","status":"COMPLETED","sponsor":"Biomedical Advanced Research and Development Authority","startDate":"2024-04-15","conditions":"Atropine Bioequivalence","enrollment":46},{"nctId":"NCT06428409","phase":"PHASE1, PHASE2","title":"A Clinical Study of MK-2870 Alone or With Other Treatments to Treat Gastrointestinal Cancers (MK-9999-02A)","status":"RECRUITING","sponsor":"Merck Sharp & Dohme LLC","startDate":"2024-06-20","conditions":"Colorectal Cancer, Pancreatic Ductal Adenocarcinoma, Biliary Tract Cancer","enrollment":220},{"nctId":"NCT05414994","phase":"","title":"Assessment of the Ocular Microbiome in Health and Disease","status":"RECRUITING","sponsor":"Vanderbilt University Medical Center","startDate":"2023-09-07","conditions":"Microbial Colonization, Eye Diseases, Ophthalmopathy","enrollment":500},{"nctId":"NCT04505566","phase":"PHASE1","title":"INflammatory MediatorS in the PathophysIology of Diabetic REtinopathy Study","status":"ACTIVE_NOT_RECRUITING","sponsor":"Stephen J. Kim, MD","startDate":"2020-11-09","conditions":"Diabetic Retinopathy","enrollment":164},{"nctId":"NCT06163989","phase":"NA","title":"Protecting the Eyes of Gamers With Lubricating Eyedrops","status":"RECRUITING","sponsor":"Aston University","startDate":"2024-09-01","conditions":"Dry Eye Syndromes, Computer Vision Syndrome","enrollment":28},{"nctId":"NCT03697876","phase":"PHASE1","title":"Safety and Tolerability of the Ophthalmic Gel PRO-165 Versus Artelac® Nightime Gel","status":"COMPLETED","sponsor":"Laboratorios Sophia S.A de C.V.","startDate":"2018-08-20","conditions":"Dry Eye Syndromes","enrollment":32},{"nctId":"NCT07234318","phase":"","title":"Non-interventional Study to Evaluate the Anti-inflammatory Effects and the Clinical Efficacy of Topical Water Free Cyclosporin 0.1% Eye Drops in Patients With Dry Eye Disease and Associated Ocular Surface Inflammation Non-responding to Artificial Tears","status":"NOT_YET_RECRUITING","sponsor":"Laboratoires Thea","startDate":"2025-12-15","conditions":"Dry Eye Disease (DED)","enrollment":25},{"nctId":"NCT07229001","phase":"NA","title":"Treating Meibomian Gland Disease in a Pediatric Population","status":"ENROLLING_BY_INVITATION","sponsor":"Illinois College of Optometry","startDate":"2024-10-01","conditions":"Dry Eye Disease, Meibomian Gland Disease","enrollment":15},{"nctId":"NCT04968912","phase":"PHASE2","title":"A Study of Nipocalimab in Adults With Primary Sjogren's Syndrome (pSS)","status":"COMPLETED","sponsor":"Janssen Research & Development, LLC","startDate":"2021-09-21","conditions":"Sjogren's Syndrome","enrollment":163},{"nctId":"NCT07078955","phase":"PHASE2","title":"A Dose Regimen Study of BRM421 Ophthalmic Solution in Patients With Dry Eye Disease","status":"NOT_YET_RECRUITING","sponsor":"BRIM Biotechnology Inc.","startDate":"2025-12","conditions":"Dry Eye Disease (DED), Keratoconjunctivitis Sicca","enrollment":99},{"nctId":"NCT04440280","phase":"PHASE2","title":"Targeting Reactive Oxygen Species Production as a Novel Therapeutic in Fuch's Endothelial Corneal Dystrophy","status":"RECRUITING","sponsor":"Massachusetts Eye and Ear Infirmary","startDate":"2020-09-16","conditions":"Fuchs Endothelial Corneal Dystrophy","enrollment":45},{"nctId":"NCT06876077","phase":"NA","title":"Evaluation of the Effectiveness of Auricular Acupuncture in Improving Dry Eye Symptoms in University Students","status":"COMPLETED","sponsor":"University of Medicine and Pharmacy at Ho Chi Minh City","startDate":"2025-03-15","conditions":"Dry Eye Symptoms","enrollment":50},{"nctId":"NCT04125134","phase":"PHASE4","title":"Predicting the Success of Dry Eye Disease Interventions Using Clinical Tests","status":"TERMINATED","sponsor":"Tufts Medical Center","startDate":"2019-10-03","conditions":"Dry Eye","enrollment":36},{"nctId":"NCT07185854","phase":"NA","title":"Medical vs Acupuncture for Dry Eye","status":"COMPLETED","sponsor":"Nadide Koca","startDate":"2024-01-15","conditions":"Dry Eye, Acupuncture","enrollment":90},{"nctId":"NCT05542381","phase":"NA","title":"The Role of Loteprednol in Reducing Post-Intravitreal Injection Related Pain","status":"COMPLETED","sponsor":"Virginia Polytechnic Institute and State University","startDate":"2022-12-22","conditions":"Age-Related Macular Degeneration","enrollment":64},{"nctId":"NCT05938699","phase":"PHASE2, PHASE3","title":"Aqueous Humor Dynamics of NCX 470 Ophthalmic Solution","status":"COMPLETED","sponsor":"Nicox Ophthalmics, Inc.","startDate":"2023-12-12","conditions":"Open Angle Glaucoma","enrollment":18},{"nctId":"NCT05902364","phase":"NA","title":"Systane® Ultra Preservative Free Lubricant Eye Drops","status":"COMPLETED","sponsor":"Alcon Research","startDate":"2023-10-28","conditions":"Dry Eye","enrollment":69},{"nctId":"NCT07110467","phase":"NA","title":"Nursing Intervention of Blinking Exercises to Alleviate Dry Eye and Enhance Daily Life in Older Adults","status":"COMPLETED","sponsor":"Norther Private Collage of Nursing","startDate":"2024-11-01","conditions":"Daily Activities, Eye Health","enrollment":100},{"nctId":"NCT07064187","phase":"PHASE4","title":"Evaluate The Improvement In Symptoms Of Patients Using Cationorm After Pterygium Surgery","status":"COMPLETED","sponsor":"Nguyen Viet Giap","startDate":"2022-06-15","conditions":"Ocular Discomfort","enrollment":100},{"nctId":"NCT07090044","phase":"PHASE4","title":"Comparing Post-intravitreal Injection Pain Scores Using Loteprednol, Bromfenac Sodium, and Artificial Tears Over a 24-hour Period","status":"COMPLETED","sponsor":"Retina Research Institute, LLC","startDate":"2021-08-20","conditions":"Vein Occlusion, Macular Degeneration Choroidal Neovascularization, Macular Edema","enrollment":77},{"nctId":"NCT05682547","phase":"NA","title":"Diquafosol vs Hyaluronic Acid for Diabetic Dry Eye","status":"COMPLETED","sponsor":"He Eye Hospital","startDate":"2022-12-01","conditions":"Diabetic Eye Problems","enrollment":99},{"nctId":"NCT05470868","phase":"PHASE1","title":"Safety and Tolerability of PRO-185","status":"COMPLETED","sponsor":"Laboratorios Sophia S.A de C.V.","startDate":"2023-02-04","conditions":"Hyperemia Eye","enrollment":22},{"nctId":"NCT06913387","phase":"NA","title":"Comparative Efficacy of Lipid Based Artificial Tears vs Aqueous Based Artificial Tears in Managing EDE","status":"ACTIVE_NOT_RECRUITING","sponsor":"Superior University","startDate":"2025-03-20","conditions":"Evaporative Dry Eye","enrollment":60},{"nctId":"NCT05896670","phase":"PHASE2","title":"Safety and Efficacy of Licaminlimab Ophthalmic Solution for the Treatment of Dry Eye Disease","status":"COMPLETED","sponsor":"Oculis","startDate":"2023-11-29","conditions":"Dry Eye Disease","enrollment":122},{"nctId":"NCT06865144","phase":"PHASE4","title":"Effect of Rhopressa on Intraocular Pressure (IOP) in Patients With Primary Open-Angle Glaucoma or Ocular Hypertension Post-SLT","status":"RECRUITING","sponsor":"East Coast Institute for Research","startDate":"2025-06-27","conditions":"Primary Open Angle Glaucoma or Ocular Hypertension","enrollment":70},{"nctId":"NCT06655441","phase":"PHASE4","title":"The Effects of 3% Trehalose Ophthalmic Solution on Corneal Epithelial Barrier Function","status":"NOT_YET_RECRUITING","sponsor":"Southern California College of Optometry at Marshall B. Ketchum University","startDate":"2025-09-01","conditions":"Dry Eye Disease (DED)","enrollment":30},{"nctId":"NCT01013077","phase":"NA","title":"The Effect of a New Emulsion in Dry Eye Patients on Tear Layer Aberrometry, Contrast Sensitivity, and Reading Ability","status":"COMPLETED","sponsor":"Southern California College of Optometry at Marshall B. Ketchum University","startDate":"2009-11","conditions":"Dry Eye Syndrome","enrollment":20},{"nctId":"NCT07000565","phase":"NA","title":"The Effect of Eye Care With Artificial Tears and Normal Saline on Ocular Surface Disease in Mechanically Ventilated Pediatric Patients","status":"COMPLETED","sponsor":"Marmara University","startDate":"2024-11-01","conditions":"Ocular Surface Disease","enrollment":42},{"nctId":"NCT06960629","phase":"","title":"The Effect of ROCK Inhibitors on Corneas of Patients With Glaucoma and Pseudophakic Bullous Keratopathy (PBK)","status":"ENROLLING_BY_INVITATION","sponsor":"University Hospital Dubrava","startDate":"2025-04-01","conditions":"Pseudophakic Bullous Keratopathy, Glaucoma","enrollment":50},{"nctId":"NCT05773963","phase":"NA","title":"A Post-market Study to Evaluate the Effects of Sodium Hyaluronate Based Eye Drops in Patients Affected by Dry Eye Disease","status":"TERMINATED","sponsor":"Montefarmaco OTC SpA","startDate":"2022-02-24","conditions":"Opthalomology/Dry Eye","enrollment":80},{"nctId":"NCT06969586","phase":"","title":"The Effect of Topical Rho-kinase Inhibitors on Corneas of Patients With Fuchs Endothelial Corneal Dystrophy","status":"ENROLLING_BY_INVITATION","sponsor":"University Hospital Dubrava","startDate":"2025-04-01","conditions":"Fuchs Endothelial Corneal Dystrophy, Cataract, Glaucoma","enrollment":50},{"nctId":"NCT06956846","phase":"PHASE4","title":"Efficacy of Topical Insuline in Corneal Epithelial Healing Post PRK","status":"NOT_YET_RECRUITING","sponsor":"Hotel Dieu de France Hospital","startDate":"2025-04-25","conditions":"Corneal Epithelial Wound Healing","enrollment":100},{"nctId":"NCT06543667","phase":"PHASE1","title":"Limbal Stem Cell Derived Exosome (LSC-Exo) Eye Drop for Treatment of Dry Eye","status":"RECRUITING","sponsor":"Iran University of Medical Sciences","startDate":"2024-08-01","conditions":"Dry Eye Syndromes","enrollment":30},{"nctId":"NCT05814367","phase":"PHASE2","title":"Clinical Investigation of Visual Acuity in Contact Lens Wearers After Instillation of Investigational Lubricating Eye Drops","status":"COMPLETED","sponsor":"Johnson & Johnson Vision Care, Inc.","startDate":"2023-04-06","conditions":"Visual Acuity","enrollment":46},{"nctId":"NCT05661851","phase":"PHASE2","title":"Clinical Evaluation of a Multidose Preservative-free Lubricating Eye Drops Contained in Novelia® Eye Dropper in Non-Contact Lens Wearing Patients","status":"COMPLETED","sponsor":"Johnson & Johnson Vision Care, Inc.","startDate":"2023-02-23","conditions":"Dry Eye","enrollment":121},{"nctId":"NCT06939959","phase":"PHASE4","title":"Evaluating the Efficacy of Topical Insulin for the Restoration of Ocular Surface Interface in Dry Eye Disease.","status":"RECRUITING","sponsor":"Khyber Teaching Hospital","startDate":"2025-04-14","conditions":"Dry Eye, Insulin Sensitivity","enrollment":126},{"nctId":"NCT06921525","phase":"PHASE1, PHASE2","title":"Comparing Efficacy of Tea Tree Oil Versus Topical Azithromycin in Treating Dry Eye","status":"NOT_YET_RECRUITING","sponsor":"Ehab Mohamed Elsayed Mohamed Saad","startDate":"2025-04-01","conditions":"Dry Eye","enrollment":44},{"nctId":"NCT05932225","phase":"NA","title":"Systane® Complete Preservative Free Lubricant Eye Drops","status":"COMPLETED","sponsor":"Alcon Research","startDate":"2023-08-18","conditions":"Dry Eye","enrollment":71},{"nctId":"NCT06898853","phase":"NA","title":"The Effect of 0.1% Topical Ciclosporin A for 12-weeks on the Eye Surface Immune Cells in Dry Eyes","status":"NOT_YET_RECRUITING","sponsor":"The University of New South Wales","startDate":"2025-05-01","conditions":"Dry Eye Disease (DED)","enrollment":60},{"nctId":"NCT01207752","phase":"NA","title":"The Efficacy of an Ocular Emulsion in Meibomian Gland Dysfunction","status":"COMPLETED","sponsor":"Southern California College of Optometry at Marshall B. Ketchum University","startDate":"2010-09","conditions":"Meibomian Gland Dysfunction","enrollment":69},{"nctId":"NCT06688630","phase":"NA","title":"Laser Acupuncture for Dry Eye Disease Due to Visual Display Terminal Use","status":"COMPLETED","sponsor":"Indonesia University","startDate":"2024-12-27","conditions":"Dry Eye Syndromes","enrollment":45},{"nctId":"NCT06163105","phase":"NA","title":"The Effect of Gland Expression on the Regeneration of Meibomian Gland","status":"COMPLETED","sponsor":"Chulalongkorn University","startDate":"2024-10-03","conditions":"Meibomian Gland Dysfunction","enrollment":64},{"nctId":"NCT05705518","phase":"PHASE4","title":"Artificial Tears, Tear Lipids and Tear Film Dynamics","status":"COMPLETED","sponsor":"University of California, Berkeley","startDate":"2023-01-30","conditions":"Dry Eye","enrollment":81},{"nctId":"NCT06860659","phase":"PHASE4","title":"Efficacy of 0.28% Sodium Hyaluronate Eye Drops in Patient with Moderate to Severe Dry Eye","status":"ENROLLING_BY_INVITATION","sponsor":"Department of Medical Services Ministry of Public Health of Thailand","startDate":"2024-09-01","conditions":"Dry Eye Disease (DED), Tear Break-Up Time, Tear Disorder","enrollment":84},{"nctId":"NCT05832996","phase":"PHASE4","title":"Cool vs Room-temperature Artificial Tears","status":"COMPLETED","sponsor":"University of Iowa","startDate":"2022-03-01","conditions":"Diabetic Retinopathy With Macular Edema of Both Eyes (Diagnosis), Central Retinal Vein Occlusion With Macular Edema, Exudative Age-Related Macular Degeneration, Unspecified Eye","enrollment":124},{"nctId":"NCT06851364","phase":"PHASE2","title":"Efficacy of 0.38% and 0.18% Sodium Hyaluronate Ocular Lubricants for Dry Eye in Adult Gazan Participants","status":"COMPLETED","sponsor":"International Islamic University Malaysia","startDate":"2022-10-30","conditions":"Dry Eye","enrollment":45},{"nctId":"NCT06671041","phase":"PHASE4","title":"Treating Lid Wiper Epitheliopathy","status":"COMPLETED","sponsor":"Southern College of Optometry","startDate":"2024-05-27","conditions":"Dry Eye, Visual Acuity","enrollment":52},{"nctId":"NCT06373653","phase":"PHASE4","title":"Study of Non-inferiority Between Manzanilla Sophia® and Meticel Ofteno® 0.5% for Providing a Soothing Sensation to the Eyes.","status":"WITHDRAWN","sponsor":"Laboratorios Sophia S.A de C.V.","startDate":"2025-02-11","conditions":"Eye Strain, Eye Strain of Both Eyes","enrollment":""},{"nctId":"NCT06824844","phase":"PHASE4","title":"The Effect of 0.05% CsA Eye Drops on Diabetic Patients with Dry Eye Disease","status":"COMPLETED","sponsor":"Peking University Third Hospital","startDate":"2021-12-02","conditions":"Dry Eye","enrollment":60},{"nctId":"NCT06822608","phase":"PHASE4","title":"Evaluation of Dexpanthenol and Hyaluronic Acid Eye Drops on Corneal Epithelialization After Trans Epithelial PRK","status":"NOT_YET_RECRUITING","sponsor":"National and Kapodistrian University of Athens","startDate":"2025-02","conditions":"Corneal Epithelial Wound Healing","enrollment":68},{"nctId":"NCT02707120","phase":"PHASE4","title":"Efficacy and Safety of Plasma Rich in Growth Factors (PRGF-Endoret) Eye-drops in the Treatment of Neurotrophic Keratitis","status":"WITHDRAWN","sponsor":"Biotechnology Institute IMASD","startDate":"2018-01-04","conditions":"Neurotrophic Keratitis","enrollment":""},{"nctId":"NCT00607776","phase":"PHASE2","title":"Artificial Tears Study in Mild to Moderate Dry Eye Patients","status":"COMPLETED","sponsor":"Abbott Medical Optics","startDate":"2007-01","conditions":"Dry Eye","enrollment":110},{"nctId":"NCT06798025","phase":"NA","title":"Three Different Modalities for Treatment of Inflammatory Punctal Stenosis","status":"COMPLETED","sponsor":"Tanta University","startDate":"2023-07-20","conditions":"Modalities, Treatment, Inflammatory Punctal Stenosis","enrollment":60},{"nctId":"NCT06784661","phase":"PHASE4","title":"Immediate Effects of Lipid-Based and Non-Lipid Artificial Tears on Corneal Aberrations","status":"NOT_YET_RECRUITING","sponsor":"University of Seville","startDate":"2025-02-01","conditions":"Aberration, Corneal Wavefront","enrollment":40},{"nctId":"NCT06752278","phase":"NA","title":"Efficacy of Pilocarpine As a Secretagogue Versus Artificial Tears for the Treatment of Dry Eye","status":"COMPLETED","sponsor":"Al-Azhar University","startDate":"2024-10-01","conditions":"Dry Eye Disease (DED)","enrollment":40},{"nctId":"NCT06726525","phase":"PHASE4","title":"Hydroxypropyl-methylcellulose and GlicoPro® Eyedrops in the Treatment of Dry Eye Disease: Clinical Study","status":"COMPLETED","sponsor":"University of Milan","startDate":"2024-02-03","conditions":"Dry Eye","enrollment":44},{"nctId":"NCT03031327","phase":"NA","title":"Safety and Efficacy of 2 Concentrations of Lubricin vs Sodium Hyaluronate in Ocular Discomfort After Refractive Surgery.","status":"COMPLETED","sponsor":"Dompé Farmaceutici S.p.A","startDate":"2017-06-17","conditions":"Ocular Discomfort","enrollment":30},{"nctId":"NCT06720428","phase":"NA","title":"Acupoint Therapy Device for Dry Eye","status":"COMPLETED","sponsor":"Shanghai 10th People's Hospital","startDate":"2021-01-01","conditions":"Dry Eye","enrollment":120},{"nctId":"NCT06188260","phase":"PHASE2","title":"Efficacy of a New Nanoemulsion Artificial Tear Targeting Dry Eye Disease","status":"COMPLETED","sponsor":"The Hong Kong Polytechnic University","startDate":"2024-01-16","conditions":"Dry Eye Syndromes","enrollment":31},{"nctId":"NCT06686368","phase":"PHASE4","title":"Comparative Efficacy Study to Demonstrate the Non-inferiority of I-DROP® MGD Versus 2 Competitor Eye Drops in Managing Evaporative Dry Eye","status":"NOT_YET_RECRUITING","sponsor":"I-MED Pharma","startDate":"2024-11-15","conditions":"Evaporative Dry Eye Disease","enrollment":60},{"nctId":"NCT06656403","phase":"NA","title":"Effect of Artificial Tears on Ocular Biometry Parameters","status":"NOT_YET_RECRUITING","sponsor":"He Eye Hospital","startDate":"2024-10-30","conditions":"Dry Eye Disease, Tear Film","enrollment":100},{"nctId":"NCT06017362","phase":"PHASE4","title":"Clinical Trial to Determine the Efficacy and Safety of Insulin Eye Drops in Dry Eye in Patients with Topical Hypotensors","status":"RECRUITING","sponsor":"Barbara Burgos Blasco","startDate":"2023-02-08","conditions":"Dry Eye, Glaucoma","enrollment":100},{"nctId":"NCT03374306","phase":"NA","title":"Topical Application of Low-concentration (0.01%) Atropine on the Human Eye With Fast and Slow Myopia Progression Rate","status":"COMPLETED","sponsor":"The Hong Kong Polytechnic University","startDate":"2018-02-01","conditions":"Myopia","enrollment":71},{"nctId":"NCT05878067","phase":"PHASE3","title":"A Study to Assess Symptom Relief and Product Tolerability of ABBV-444 Drops in Adult Participants","status":"COMPLETED","sponsor":"AbbVie","startDate":"2023-06-27","conditions":"Dry Eye Syndrome","enrollment":40},{"nctId":"NCT04630158","phase":"PHASE2","title":"Study of Efficacy and Safety of SAF312 Eye Drops in Subjects With Post-operative Corneal Induced Chronic Pain (CICP)","status":"COMPLETED","sponsor":"Novartis Pharmaceuticals","startDate":"2021-04-21","conditions":"Chronic Ocular Pain","enrollment":153},{"nctId":"NCT05290727","phase":"NA","title":"Efficacy of \"Aquoral Lipo\" Artificial Tears in Contact Lens Wearers With Discomfort","status":"COMPLETED","sponsor":"Instituto Universitario de Oftalmobiología Aplicada (Institute of Applied Ophthalmobiology) - IOBA","startDate":"2022-03-01","conditions":"Contact Lens Complication","enrollment":41},{"nctId":"NCT06624384","phase":"PHASE1","title":"Efficacy and Safety of Topical Cyclosporine 0.05% and Lifitgrast on the Ocular Surface Symptom After Photorefractive Keratectomy in Feiz Hospital, Isfahan, 2024","status":"NOT_YET_RECRUITING","sponsor":"Mohsen Pourazizi","startDate":"2024-10-30","conditions":"Ocular Surface Symptom, Ocular Surface Disease, Eye Pain","enrollment":150},{"nctId":"NCT04118920","phase":"PHASE1","title":"Safety of Topical Insulin Drops for Open-angle Glaucoma","status":"ACTIVE_NOT_RECRUITING","sponsor":"Centre hospitalier de l'Université de Montréal (CHUM)","startDate":"2023-03-27","conditions":"Glaucoma","enrollment":18},{"nctId":"NCT05660447","phase":"PHASE2, PHASE3","title":"A Multi-Center Study on the Use of Rho-Kinase Inhibitor to Reduce or Prevent PVR in RRD Eyes at High Risk for PVR","status":"ACTIVE_NOT_RECRUITING","sponsor":"Wills Eye","startDate":"2023-02-06","conditions":"Rhegmatogenous Retinal Detachment, Proliferative Vitreoretinopathy","enrollment":80},{"nctId":"NCT02120079","phase":"PHASE4","title":"The Utility of IVCM to Assess Cellular Response and Efficacy of Long-term Topical Steroid Treatment in Patients With DED","status":"COMPLETED","sponsor":"Tufts Medical Center","startDate":"2014-02","conditions":"Dry Eye Disease","enrollment":37},{"nctId":"NCT06131476","phase":"PHASE1","title":"Clinical Investigation of Visual Acuity in Contact Lens Wearers After Instillation of a Lipid- Based Lubricating Eye Drop","status":"COMPLETED","sponsor":"Johnson & Johnson Vision Care, Inc.","startDate":"2020-09-16","conditions":"Visual Acuity","enrollment":32},{"nctId":"NCT04393441","phase":"PHASE3","title":"Efficacy and Safety of a New Artificial Tear Formulation Compared With Systane Ultra Multidose in Participants With Dry Eye Disease","status":"COMPLETED","sponsor":"Allergan","startDate":"2020-06-29","conditions":"Dry Eye Disease (DED)","enrollment":400},{"nctId":"NCT06461975","phase":"PHASE3","title":"Effect of Benoxinate Hydrochloride Eye Drops on The Premature Infant Pain Profile Score During Retinopathy of Prematurity Screening","status":"COMPLETED","sponsor":"Alexandria University","startDate":"2023-01-01","conditions":"Retinopathy of Prematurity","enrollment":88},{"nctId":"NCT06190054","phase":"NA","title":"Evaluation of Performance and Safety of Eye Drops With Hydroxypropyl-methylcellulose and Inositol in Drye Eye Disease","status":"UNKNOWN","sponsor":"Fidia Farmaceutici s.p.a.","startDate":"2023-02-06","conditions":"Dry Eye Disease Associated to Asthenopia and Accommodative Effort in Video Display Terminal Users","enrollment":100},{"nctId":"NCT04604834","phase":"NA","title":"Autologous Platelet-rich Plasma (APRP) in the Treatment of Neurotrophic Keratopathy","status":"RECRUITING","sponsor":"Universidad Autonoma de Nuevo Leon","startDate":"2020-11-01","conditions":"Neurotrophic Keratopathy","enrollment":39},{"nctId":"NCT03693183","phase":"PHASE2","title":"Efficacy Study of Ketorolac and HPMC to Treat Dry Eye","status":"WITHDRAWN","sponsor":"ORA, Inc.","startDate":"2009-03","conditions":"Dry Eye","enrollment":""},{"nctId":"NCT06358456","phase":"NA","title":"Influence of Artificial Tears on Keratometry and Biometry Measurements With Different Devices","status":"COMPLETED","sponsor":"University Clinic Frankfurt","startDate":"2020-11-20","conditions":"Healthy","enrollment":145}],"_emaApprovals":[],"_faersSignals":[{"count":1,"reaction":"CATARACT"},{"count":1,"reaction":"EYE DISCHARGE"},{"count":1,"reaction":"EYE PAIN"},{"count":1,"reaction":"PANCREATIC CARCINOMA"},{"count":1,"reaction":"PANCREATITIS ACUTE"}],"crossReferences":{"chemblId":"CHEMBL5940488"},"_approvalHistory":[],"publicationCount":6,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Artificial tears eye-drops","genericName":"Artificial tears eye-drops","companyName":"Hotel Dieu de France Hospital","companyId":"hotel-dieu-de-france-hospital","modality":"Small molecule","firstApprovalDate":"","enrichmentLevel":3,"visitCount":1,"regulatoryByCountry":[{"country_code":"CA","regulator":"Health Canada","status":"approved","approval_date":null,"mah":"","brand_name_local":"","application_number":""},{"country_code":"US","regulator":"FDA","status":"approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null}],"trialStats":{"total":0,"withResults":0},"validation":{"fieldsValidated":1,"lastValidatedAt":"2026-04-20T05:29:59.692064+00:00","fieldsConflicting":0,"overallConfidence":0.95},"verificationStatus":"enriching","dataCompleteness":{"mechanism":false,"indications":false,"safety":false,"trials":true,"score":1}}