{"id":"artesunate-sulphadoxin-pyrimethamine-chloroquine","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Nausea"},{"rate":"5-10%","effect":"Vomiting"},{"rate":"5-10%","effect":"Diarrhea"},{"rate":"5-10%","effect":"Abdominal pain"},{"rate":"5-10%","effect":"Headache"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Artesunate-sulphadoxin/pyrimethamine is a combination of an artemisinin derivative and two antimalarial drugs. Artesunate inhibits the parasite's growth by generating reactive oxygen species, while sulphadoxin and pyrimethamine target the parasite's dihydrofolate reductase and dihydropteroate synthase enzymes, respectively. Chloroquine, on the other hand, targets the parasite's digestive enzyme, heme polymerase, which is essential for the parasite's survival.","oneSentence":"Artesunate-sulphadoxin/pyrimethamine works by inhibiting the growth of malaria parasites, while chloroquine targets the parasite's digestive enzyme.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:02:39.509Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Treatment of uncomplicated malaria"},{"name":"Treatment of severe malaria"}]},"trialDetails":[{"nctId":"NCT00682578","phase":"PHASE3","title":"A Comparative Study of Artekin With Standard Malarial Treatment Regimes in Afghanistan","status":"COMPLETED","sponsor":"University of Oxford","startDate":"2007-07","conditions":"Uncomplicated Falciparum Malaria, Vivax Malaria","enrollment":1086}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":23,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"artesunate-sulphadoxin/pyrimethamine, chloroquine","genericName":"artesunate-sulphadoxin/pyrimethamine, chloroquine","companyName":"University of Oxford","companyId":"university-of-oxford","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Artesunate-sulphadoxin/pyrimethamine works by inhibiting the growth of malaria parasites, while chloroquine targets the parasite's digestive enzyme. Used for Treatment of uncomplicated malaria, Treatment of severe malaria.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}