{"id":"artesunate-sulfadoxine-pyrimethamine","safety":{"commonSideEffects":[{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Vomiting"},{"rate":null,"effect":"Abdominal pain"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Diarrhea"},{"rate":null,"effect":"Rash"},{"rate":null,"effect":"Stevens-Johnson syndrome (rare)"}]},"_chembl":{"chemblId":"CHEMBL3137690","moleculeType":"Unknown","molecularWeight":"559.05"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Artesunate, a semi-synthetic artemisinin derivative, acts as a fast-acting blood schizonticide that rapidly reduces parasite biomass through oxidative stress mechanisms. Sulfadoxine-pyrimethamine is a long-acting antifolate combination that inhibits dihydrofolate reductase and dihydropteroate synthase, blocking nucleotide synthesis. Together, they provide complementary mechanisms targeting different stages of the parasite lifecycle and reducing the risk of resistance.","oneSentence":"Artesunate kills malaria parasites by generating reactive oxygen species, while sulfadoxine-pyrimethamine inhibits folate synthesis in the parasite, providing synergistic antimalarial activity.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:30:26.262Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Uncomplicated malaria caused by Plasmodium falciparum"},{"name":"Malaria treatment in endemic regions"}]},"trialDetails":[{"nctId":"NCT06173206","phase":"PHASE3","title":"Parasite Clearance and Protection from Infection (PCPI) in Cameroon","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2024-06-10","conditions":"Malaria","enrollment":902},{"nctId":"NCT06166498","phase":"PHASE3","title":"Parasite Clearance and Protection From Infection (PCPI) in Zambia","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2024-07-24","conditions":"Malaria","enrollment":600},{"nctId":"NCT04783051","phase":"PHASE3","title":"Comparison of ISTp- PYRAMAX-US-RDT to IPTp-SP to Prevent Malaria in Pregnant Women in DRC (ULTRAPYRAPREG)","status":"COMPLETED","sponsor":"University of Kinshasa","startDate":"2021-05-06","conditions":"Malaria in Pregnancy","enrollment":250},{"nctId":"NCT03083847","phase":"PHASE1","title":"Dose Escalation PfSPZ-CVac","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"2017-06-05","conditions":"Malaria","enrollment":55},{"nctId":"NCT01707199","phase":"NA","title":"SPK Study in Afghanistan","status":"COMPLETED","sponsor":"University of Oxford","startDate":"2012-10","conditions":"Uncomplicated P. 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