{"id":"artesunate-as","safety":{"commonSideEffects":[{"rate":null,"effect":"Post-artesunate delayed hemolysis"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Vomiting"},{"rate":null,"effect":"Diarrhea"},{"rate":null,"effect":"Abdominal pain"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Artesunate is a semi-synthetic artemisinin derivative that acts as a prodrug, rapidly converted to dihydroartemisinin in vivo. The active metabolite generates free radicals and reactive oxygen species through interaction with heme and iron, causing oxidative damage to Plasmodium parasites. This mechanism is effective against multiple Plasmodium species and artemisinin-resistant strains.","oneSentence":"Artesunate generates reactive oxygen species that damage parasite membranes and proteins, killing malaria parasites.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:18:34.902Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Severe malaria (all Plasmodium species)"},{"name":"Uncomplicated malaria (artemisinin-based combination therapy component)"},{"name":"Cerebral malaria"}]},"trialDetails":[{"nctId":"NCT06967519","phase":"PHASE4","title":"OPTImizing Malaria And HIV Treatment in a Shifting Landscape in Africa","status":"RECRUITING","sponsor":"Yale University","startDate":"2025-12-18","conditions":"Malaria, Hiv","enrollment":380},{"nctId":"NCT06806956","phase":"","title":"Severe Malaria in Remote Areas- Closing the Evidence Gap","status":"ENROLLING_BY_INVITATION","sponsor":"Tropical Diseases Research Centre, Zambia","startDate":"2024-03-10","conditions":"Severe Malaria","enrollment":2016},{"nctId":"NCT07362498","phase":"","title":"Health Systems Implementation and Molecular Surveillance of Multiple First-Line Treatments for Uncomplicated Malaria in Western Kenya","status":"COMPLETED","sponsor":"Strathmore University","startDate":"2020-06-01","conditions":"Malaria Falciparum","enrollment":316},{"nctId":"NCT05750459","phase":"PHASE4","title":"Pharmacokinetic Study of IV Artesunate to Treat Children With Severe Malaria","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"2023-11-29","conditions":"Plasmodium Falciparum Infection","enrollment":90},{"nctId":"NCT04675931","phase":"PHASE2","title":"To Evaluate Efficacy, Safety, Tolerability and PK of Intravenous Cipargamin in Participants With Severe Plasmodium Falciparum Malaria","status":"COMPLETED","sponsor":"Novartis Pharmaceuticals","startDate":"2022-03-07","conditions":"Severe Malaria","enrollment":254},{"nctId":"NCT06519994","phase":"PHASE2","title":"Feasibility of Intravaginal Artesunate as Adjuvant HPV & Cervical Precancer Treatment in Kenya","status":"ACTIVE_NOT_RECRUITING","sponsor":"UNC Lineberger Comprehensive Cancer Center","startDate":"2025-01-22","conditions":"Human Immunodeficiency Virus, Human Papillomavirus, Cervical Precancer","enrollment":120},{"nctId":"NCT06962319","phase":"PHASE3","title":"Safety of Antimalarials in the FIRst trimEster","status":"RECRUITING","sponsor":"Liverpool School of Tropical Medicine","startDate":"2025-09-30","conditions":"Malaria, Pregnancy, Malaria, Antepartum, Malaria (Uncomplicated)","enrollment":1510},{"nctId":"NCT05951595","phase":"PHASE3","title":"A Study to Find Out if a Combination of 3 Medicines for the Treatment of Malaria Works as Well and is as Safe and Tolerable as Combinations of 2 Medicines","status":"RECRUITING","sponsor":"University of Oxford","startDate":"2025-09-11","conditions":"Uncomplicated Plasmodium Falciparum Malaria","enrollment":1680},{"nctId":"NCT03923725","phase":"PHASE3","title":"A Trial to Compare the Efficacy, Safety and Tolerability of Combinations of 3 Anti-malarial Drugs Against Combina-tions of 2 Anti-malarial Drugs.","status":"COMPLETED","sponsor":"University of Oxford","startDate":"2020-09-01","conditions":"Plasmodium Falciparum Malaria (Uncomplicated)","enrollment":2583},{"nctId":"NCT05690841","phase":"PHASE3","title":"FocaL Mass Drug Administration for Vivax Malaria Elimination","status":"RECRUITING","sponsor":"University of California, San Francisco","startDate":"2024-10-14","conditions":"Plasmodium Vivax Malaria, Malaria","enrollment":7530},{"nctId":"NCT04098744","phase":"PHASE2","title":"Artesunate Vaginal Inserts for the Treatment of Cervical Intraepithelial Neoplasia (CIN2/3)","status":"RECRUITING","sponsor":"Frantz Viral Therapeutics, LLC","startDate":"2020-09-09","conditions":"CIN 2/3, HPV Infection, Pre-Cancerous Dysplasia","enrollment":78},{"nctId":"NCT05343312","phase":"PHASE4","title":"In Vivo Efficacy of Artemether-Lumefantrine, Amodiaquine-Artesunate, Dihydroartemisinin-Piperaquine, and Pironaridine-Artesunate in Mozambique","status":"COMPLETED","sponsor":"Centro de Investigacao em Saude de Manhica","startDate":"2022-03-16","conditions":"Malaria","enrollment":870},{"nctId":"NCT06263582","phase":"PHASE1","title":"Pharmacokinetics of Intravaginal, Self-administered Artesunate Vaginal Pessaries Among Women in Kenya","status":"COMPLETED","sponsor":"UNC Lineberger Comprehensive Cancer Center","startDate":"2024-05-29","conditions":"Cervix Cancer, Cervix Intraepithelial Neoplasia Grade 3, Cervix; 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