{"id":"artesunate-amodiaquine-primaquine","safety":{"commonSideEffects":[{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Vomiting"},{"rate":null,"effect":"Abdominal pain"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Hemolysis (in G6PD-deficient patients, primaquine-related)"}]},"_chembl":{"chemblId":"CHEMBL361497","moleculeType":"Small molecule","molecularWeight":"384.43"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Artesunate is an artemisinin derivative that generates reactive oxygen species to damage parasite proteins and DNA. Amodiaquine is a quinoline antimalarial that intercalates into parasite DNA and inhibits heme polymerization. Primaquine is a 8-aminoquinoline that is particularly effective against hypnozoites (dormant forms in P. vivax and P. ovale) and sexual stages, addressing the major limitation of the artesunate-amodiaquine combination alone.","oneSentence":"This combination therapy kills malaria parasites through multiple mechanisms: artesunate and amodiaquine target the parasite's hemoglobin digestion and DNA replication, while primaquine eliminates dormant liver stages and gametocytes to prevent transmission and relapse.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:43:01.538Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Uncomplicated malaria (Plasmodium falciparum and other species)"},{"name":"Prevention of malaria relapse in P. vivax and P. ovale infections"}]},"trialDetails":[{"nctId":"NCT06923592","phase":"PHASE3","title":"Serological Testing and Treatment for Plasmodium Vivax Malaria: a Trial in Ethiopia and Madagascar","status":"RECRUITING","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2025-05-12","conditions":"Malaria Vivax, Malaria Falciparum, Plasmodium Vivax","enrollment":19200},{"nctId":"NCT05550909","phase":"PHASE2","title":"Gametocytocidal and Transmission-blocking Efficacy of ASAQ and ALAQ With or Without PQ in Mali","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2022-10-17","conditions":"Malaria,Falciparum","enrollment":100},{"nctId":"NCT02851108","phase":"PHASE2","title":"Methylene Blue Against Falciparum Malaria in Burkina Faso","status":"COMPLETED","sponsor":"Heidelberg University","startDate":"2016-10","conditions":"Malaria, Falciparum","enrollment":100},{"nctId":"NCT03773536","phase":"PHASE4","title":"Efficacy and Safety of Artesunate + Amodiaquine With SLD of Primaquine for Treatment of Falciparum Malaria in Zanzibar","status":"COMPLETED","sponsor":"Professor Anders Björkman","startDate":"2017-05-09","conditions":"Plasmodium Falciparum Malaria","enrollment":146},{"nctId":"NCT00158548","phase":"PHASE3","title":"ACT With Chloroquine, Amodiaquine & Sulphadoxine-pyrimethamine in Pakistan","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2001-06","conditions":"Malaria, Falciparum Malaria, Vivax Malaria","enrollment":650},{"nctId":"NCT01288820","phase":"PHASE3","title":"Study of ACTs Plus Primaquine for Uncomplicated Plasmodium Vivax Malaria","status":"COMPLETED","sponsor":"University of Oxford","startDate":"2011-01","conditions":"Vivax Malaria","enrollment":331}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":10,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Artesunate-amodiaquine + primaquine","genericName":"Artesunate-amodiaquine + primaquine","companyName":"University of Oxford","companyId":"university-of-oxford","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This combination therapy kills malaria parasites through multiple mechanisms: artesunate and amodiaquine target the parasite's hemoglobin digestion and DNA replication, while primaquine eliminates dormant liver stages and gametocytes to prevent transmission and relapse. Used for Uncomplicated malaria (Plasmodium falciparum and other species), Prevention of malaria relapse in P. vivax and P. ovale infections.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}