{"id":"arterakin-dha-ppq","safety":{"commonSideEffects":[{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Abdominal pain"},{"rate":null,"effect":"Diarrhea"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Dihydroartemisinin is an artemisinin derivative that generates free radicals upon interaction with parasite heme, causing oxidative damage to Plasmodium parasites. Piperaquine is a quinoline-type antimalarial that accumulates in the parasite's food vacuole and inhibits hemoglobin digestion. The combination provides synergistic antimalarial activity with a lower risk of resistance development compared to monotherapy.","oneSentence":"Arterakin combines dihydroartemisinin (DHA) and piperaquine (PPQ) to kill malaria parasites by generating reactive oxygen species and disrupting parasite hemoglobin digestion.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:18:34.554Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Uncomplicated malaria caused by Plasmodium falciparum"},{"name":"Uncomplicated malaria caused by Plasmodium vivax"}]},"trialDetails":[{"nctId":"NCT01775592","phase":"PHASE4","title":"Plasmodium Falciparum Artemisinin Resistance Vietnam","status":"COMPLETED","sponsor":"National Institute of Malariology, Parasitology and Entomology, Vietnam","startDate":"2012-09","conditions":"Plasmodium Falciparum","enrollment":95}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":79,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Arterakin (DHA-PPQ)","genericName":"Arterakin (DHA-PPQ)","companyName":"National Institute of Malariology, Parasitology and Entomology, Vietnam","companyId":"national-institute-of-malariology-parasitology-and-entomology-vietnam","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Arterakin (DHA-PPQ) is a small molecule intervention studied for its efficacy against Plasmodium Falciparum. It was investigated in the \"Plasmodium Falciparum Artemisinin Resistance Vietnam\" clinical trial, which monitored its effectiveness in patients with uncomplicated falciparum malaria.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}