{"id":"artemotil","rwe":[],"tags":[{"label":"artemotil","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"P01BE04","category":"atc"},{"label":"Active","category":"status"},{"label":"Amebicides","category":"pharmacology"},{"label":"Anthelmintics","category":"pharmacology"},{"label":"Anti-Infective Agents","category":"pharmacology"},{"label":"Antimalarials","category":"pharmacology"},{"label":"Antiparasitic Agents","category":"pharmacology"},{"label":"Antiplatyhelmintic Agents","category":"pharmacology"},{"label":"Antiprotozoal Agents","category":"pharmacology"},{"label":"Schistosomicides","category":"pharmacology"}],"phase":"phase_2","safety":{"commonSideEffects":[]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"arteether","offLabel":[],"synonyms":["artemotil","arteether","dihydroartemisinin ethyl ether","dihydroqinghaosu ethyl ether"],"timeline":[],"brandName":"Arteether","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"artemotil","explanation":"Imagine a strong detergent that breaks down the protective layer around a cell. Arteether is like that detergent, but for malaria parasites. It gets inside the parasite's cell and breaks down its membrane, causing the parasite to die.","oneSentence":"Arteether works by targeting and disrupting the cell membrane of malaria parasites, ultimately leading to their death.","technicalDetail":"Arteether exerts its antimalarial activity by generating reactive oxygen species (ROS) that damage the parasite's cell membrane, ultimately leading to cell lysis and parasite death."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/246","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=ARTEMOTIL","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=ARTEMOTIL","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T08:45:45.252990","biosimilars":[],"competitors":[{"drugName":"artemether","drugSlug":"artemether","fdaApproval":"2009-04-07","relationship":"same-class"},{"drugName":"artesunate","drugSlug":"artesunate","fdaApproval":"2020-05-26","patentExpiry":"Feb 16, 2044","patentStatus":"Patent protected","relationship":"same-class"}],"genericName":"artemotil","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"artemether","brandName":"artemether","genericName":"artemether","approvalYear":"2009","relationship":"same-class"},{"drugId":"artesunate","brandName":"artesunate","genericName":"artesunate","approvalYear":"2020","relationship":"same-class"}],"trialDetails":[{"nctId":"NCT03093129","phase":"PHASE2","title":"Safety and Effectiveness Study of Pre-operative Artesunate in Stage II/III Colorectal Cancer (NeoART-V)","status":"UNKNOWN","sponsor":"The 108 Military Central Hospital","startDate":"2018-01-08","conditions":["Colorectal Cancer"],"enrollment":200,"completionDate":"2022-12"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"XGL7GFB9YI","CHEBI":"CHEBI:135335","INN_ID":"6457","UMLSCUI":"C0052427","ChEMBL_ID":"CHEMBL301267","KEGG_DRUG":"D07361","DRUGBANK_ID":"DB13851","PUBCHEM_CID":"3000469","IUPHAR_LIGAND_ID":"9958","MESH_SUPPLEMENTAL_RECORD_UI":"C055141"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":14,"therapeuticAreas":["Infectious Disease"],"atcClassification":{"source":"DrugCentral","atcCode":"P01BE04","allCodes":["P01BE04"]},"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Arteether, also known as artemotil, is a small molecule drug in the artemotil class. It is a derivative of artemisinin, a compound extracted from the Artemisia annua plant. Arteether is used to treat malaria, a disease caused by Plasmodium parasites. The commercial status of arteether is unclear, and it is not FDA-approved. Further research is needed to determine its safety and efficacy.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}