{"id":"artemether-sublingual-spray","safety":{"commonSideEffects":[{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Vomiting"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Abdominal pain"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Artemether, a semi-synthetic derivative of artemisinin from Artemisia annua, acts as a fast-acting antimalarial agent. Upon activation by heme iron in Plasmodium parasites, it generates highly reactive oxygen species that cause oxidative damage to parasite proteins, lipids, and DNA. The sublingual spray formulation is designed to provide rapid systemic absorption for quick therapeutic effect.","oneSentence":"Artemether is an artemisinin derivative that kills malaria parasites by generating reactive oxygen species that damage parasite proteins and membranes.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:02:37.056Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Malaria (Plasmodium falciparum and other species)"}]},"trialDetails":[{"nctId":"NCT02263950","phase":"PHASE1, PHASE2","title":"A Phase 1/2a Study of LON002 in Subjects With Advanced Solid Tumours","status":"UNKNOWN","sponsor":"LondonPharma Ltd.","startDate":"2014-10","conditions":"Solid Tumours","enrollment":87},{"nctId":"NCT01258049","phase":"PHASE3","title":"Superiority of ArTiMist Versus Quinine in Children With Severe Malaria","status":"COMPLETED","sponsor":"Proto Pharma Ltd","startDate":"2010-12","conditions":"Plasmodium Falciparum Malaria","enrollment":151},{"nctId":"NCT01047436","phase":"PHASE2","title":"Efficacy of ArTiMist™ in Children","status":"COMPLETED","sponsor":"Proto Pharma Ltd","startDate":"2009-12","conditions":"Falciparum Malaria","enrollment":31}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":3,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["ArTiMist"],"phase":"phase_3","status":"active","brandName":"Artemether Sublingual Spray","genericName":"Artemether Sublingual Spray","companyName":"Proto Pharma Ltd","companyId":"proto-pharma-ltd","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Artemether is an artemisinin derivative that kills malaria parasites by generating reactive oxygen species that damage parasite proteins and membranes. Used for Malaria (Plasmodium falciparum and other species).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}