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The 3-day regimen is a shortened treatment course compared to standard 6-dose regimens, designed to improve adherence while maintaining efficacy.","oneSentence":"Artemether-lumefantrine is a fixed-dose combination antimalarial that kills malaria parasites through multiple mechanisms: artemether rapidly reduces parasite biomass while lumefantrine eliminates remaining parasites and prevents recrudescence.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:02:36.063Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Uncomplicated malaria caused by Plasmodium falciparum"},{"name":"Malaria treatment in endemic regions"}]},"trialDetails":[{"nctId":"NCT06735209","phase":"PHASE1","title":"First-in-Human PfSPZ-LARC2 Vaccination/CHMI","status":"ACTIVE_NOT_RECRUITING","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"2025-07-23","conditions":"Malaria","enrollment":22},{"nctId":"NCT07235033","phase":"PHASE2","title":"Platform Study to Evaluate the Efficacy and Safety of Anti-malarial Agents in Participants With Uncomplicated Plasmodium Falciparum Malaria (Cohort B2)","status":"COMPLETED","sponsor":"Novartis Pharmaceuticals","startDate":"2024-01-23","conditions":"Uncomplicated Plasmodium Falciparum Malaria","enrollment":60},{"nctId":"NCT07403643","phase":"PHASE4","title":"Investigating the Pharmacology of Tafenoquine in Papua New Guinean Children With Uncomplicated Malaria","status":"NOT_YET_RECRUITING","sponsor":"Curtin University","startDate":"2026-04","conditions":"Uncomplicated Malaria","enrollment":60},{"nctId":"NCT05842954","phase":"PHASE3","title":"Efficacy, Safety and Tolerability of KLU156 in Adults and Children With Uncomplicated P. 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