{"id":"aromatase-inhibitors-femara","safety":{"commonSideEffects":[{"rate":"19-29","effect":"Hot flashes"},{"rate":"19-25","effect":"Arthralgia/joint pain"},{"rate":"13-18","effect":"Fatigue"},{"rate":"7-13","effect":"Headache"},{"rate":"null","effect":"Osteoporosis/bone loss"},{"rate":"7-12","effect":"Vaginal dryness"},{"rate":"9-13","effect":"Nausea"}]},"_chembl":{"chemblId":"CHEMBL5760702","moleculeType":null,"molecularWeight":"276.36"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Aromatase inhibitors like letrozole selectively block the cytochrome P450 aromatase enzyme, which catalyzes the final step of estrogen synthesis in postmenopausal women. By reducing circulating estrogen levels, these agents deprive estrogen receptor-positive breast cancer cells of growth signals. This mechanism is particularly effective in hormone-dependent breast cancers where estrogen drives proliferation.","oneSentence":"Femara (letrozole) inhibits the aromatase enzyme to block conversion of androgens to estrogen in postmenopausal women with hormone receptor-positive breast cancer.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:43:04.347Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hormone receptor-positive, HER2-negative early-stage breast cancer (adjuvant therapy)"},{"name":"Metastatic hormone receptor-positive breast cancer"},{"name":"Extended therapy following tamoxifen in postmenopausal women"}]},"trialDetails":[{"nctId":"NCT05307705","phase":"PHASE1","title":"A Study of LOXO-783 in Patients With Breast Cancer/Other Solid Tumors","status":"ACTIVE_NOT_RECRUITING","sponsor":"Eli Lilly and Company","startDate":"2022-05-11","conditions":"Breast 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(NICHD)","startDate":"1995-06-08","conditions":"Congenital Adrenal Hyperplasia (CAH)","enrollment":66},{"nctId":"NCT07005557","phase":"PHASE3","title":"Chemo-free in Older (≥65) Node-Positive ER+/HER2- Breast Cancer","status":"NOT_YET_RECRUITING","sponsor":"Fudan University","startDate":"2025-06-15","conditions":"Breast Cancer, Adjuvant Therapy","enrollment":1244},{"nctId":"NCT04188548","phase":"PHASE1","title":"A Study of LY3484356 in Participants With Advanced or Metastatic Breast Cancer or Endometrial Cancer","status":"ACTIVE_NOT_RECRUITING","sponsor":"Eli Lilly and Company","startDate":"2019-12-10","conditions":"Breast Cancer, Advanced Breast Cancer, Metastatic Breast Cancer","enrollment":500},{"nctId":"NCT06985186","phase":"PHASE4","title":"Does The Addition Of Letrozole To Ultra-Long GnRH Agonists Help Adenomyosis Patients in ART? 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