{"id":"arnica-montana","safety":{"commonSideEffects":[{"rate":null,"effect":"Skin irritation or contact dermatitis (topical)"},{"rate":null,"effect":"Gastrointestinal upset (oral)"},{"rate":null,"effect":"Allergic reactions in sensitive individuals"}]},"_chembl":null,"_dailymed":{"setId":"4b6fce7b-8a2e-b318-e063-6394a90ac211","title":"VOICECALM (ARNICA MONTANA WHOLE, ARISAEMA TRIPHYLLUM ROOT, FERROSOFERRIC PHOSPHATE, CALCIUM SULFIDE, TOXICODENDRON PUBESCENS LEAF, SPONGIA OFFICINALIS SKELETON, ROASTED) PELLET [BOIRON]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Arnica montana contains bioactive compounds that inhibit inflammatory mediators and nuclear factor-kappa B (NF-κB) signaling, reducing pro-inflammatory cytokine production. These constituents also promote angiogenesis and fibroblast proliferation, facilitating wound healing and tissue repair. The extract has been traditionally used topically and orally to manage bruising, swelling, and musculoskeletal trauma.","oneSentence":"Arnica montana is a herbal extract that reduces inflammation and promotes tissue healing through multiple phytochemical constituents including sesquiterpenes and flavonoids.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:18:12.835Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Bruising and contusions"},{"name":"Muscle soreness and inflammation"},{"name":"Wound healing and tissue repair"},{"name":"Post-surgical swelling and pain"}]},"trialDetails":[{"nctId":"NCT07445568","phase":"NA","title":"Home-Based Quadriceps Isometric Exercise for Knee Osteoarthritis Pain","status":"COMPLETED","sponsor":"Universidad del Valle de México, Campus Cuernavaca","startDate":"2025-09-01","conditions":"Older Adults (60 - 85 Years Old), OA Knee","enrollment":50},{"nctId":"NCT03944629","phase":"","title":"Efficacy of Arnica Montana in Reducing Postoperative Edema and Pain","status":"COMPLETED","sponsor":"Tufts University","startDate":"2018-01-26","conditions":"Arnica, Third Molar Extraction","enrollment":53},{"nctId":"NCT07162454","phase":"NA","title":"Effectiveness of CBD for Neuropathic Pain in Diabetic Foot Neuropathy","status":"COMPLETED","sponsor":"Universidad Complutense de Madrid","startDate":"2024-11-01","conditions":"Xerosis Cutis, Neuropathic Pain Associated With Diabetic Peripheral Neuropathy","enrollment":23},{"nctId":"NCT05048628","phase":"NA","title":"The Effect of Ice, Green Tea and Arnica Montana Application on Post-Operative Intubation Related Sore Throat and Hoarseness","status":"COMPLETED","sponsor":"Eastern Mediterranean University","startDate":"2021-06-14","conditions":"Sore Throat, Hoarseness","enrollment":176},{"nctId":"NCT06822478","phase":"PHASE3","title":"Arnica Tincture Fot the Treatment of Cutaneous Leishmaniasis II.","status":"NOT_YET_RECRUITING","sponsor":"Universidad de Antioquia","startDate":"2025-10","conditions":"Leishmaniasis, Cutaneous","enrollment":96},{"nctId":"NCT05094908","phase":"PHASE1","title":"Arnica Tincture Fot the Treatment of Cutaneous Leishmaniasis","status":"ACTIVE_NOT_RECRUITING","sponsor":"Universidad de Antioquia","startDate":"2023-05-03","conditions":"Leishmaniasis, Cutaneous","enrollment":16},{"nctId":"NCT05958251","phase":"","title":"The Use of Arnica Montana in the Cicatrization of the Umbilical Cord","status":"COMPLETED","sponsor":"Ospedale Buon Consiglio Fatebenefratelli","startDate":"2022-05-30","conditions":"Umbilical Cord Issue","enrollment":326},{"nctId":"NCT06271135","phase":"NA","title":"Assessing the Quality of Life of Patients With Rosacea","status":"COMPLETED","sponsor":"Medical University of Bialystok","startDate":"2017-05-08","conditions":"Rosacea","enrollment":160},{"nctId":"NCT06193720","phase":"NA","title":"The Impact of Arnica Montana Following the Surgical Extraction of Impacted Third Molars","status":"COMPLETED","sponsor":"Saint-Joseph University","startDate":"2022-02-03","conditions":"Edema, Pain, Trismus","enrollment":10},{"nctId":"NCT04677712","phase":"PHASE4","title":"Effects of Mitigation Treatments on Bruising of CCH-aaes Treatment of Buttock Cellulite","status":"COMPLETED","sponsor":"Endo Pharmaceuticals","startDate":"2020-12-28","conditions":"Edematous Fibrosclerotic Panniculopathy (EFP), Cellulite","enrollment":48},{"nctId":"NCT05690100","phase":"NA","title":"Evaluation of the Use of Ozone Gel Versus Hyaluronic Acid Gel on Palatal Wound Healing .","status":"UNKNOWN","sponsor":"Cairo University","startDate":"2023-01","conditions":"Palate; Wound","enrollment":56},{"nctId":"NCT05283434","phase":"PHASE2, PHASE3","title":"Arnica and the Management of Pain in Acute Musculoskeletal Extremity Injuries","status":"UNKNOWN","sponsor":"Children's Hospitals and Clinics of Minnesota","startDate":"2021-07-15","conditions":"Pain, Muscle, Pain, Acute","enrollment":324},{"nctId":"NCT00363038","phase":"NA","title":"Effects of Topical Vitamin K, Vitamin K and Retinol, and Arnica on Post-Laser Bruising","status":"COMPLETED","sponsor":"Northwestern University","startDate":"2006-07","conditions":"Ecchymosis","enrollment":16},{"nctId":"NCT04683263","phase":"NA","title":"Immediate and Mid-term Effect of a Natural Topical Product in Patients With Musculoskeletal Pain","status":"COMPLETED","sponsor":"Uriach Consumer Healthcare","startDate":"2019-06-01","conditions":"Musculoskeletal Pain, Chronic Pain, Joint Pain","enrollment":200},{"nctId":"NCT04533269","phase":"NA","title":"A Study of Topical Arnica & Ledum on Bruise Reduction in HNV","status":"UNKNOWN","sponsor":"Cearna, Inc.","startDate":"2021-07-31","conditions":"Bruise, Contusion","enrollment":150},{"nctId":"NCT04536948","phase":"NA","title":"Cold Application in Lateral Epicondylitis","status":"COMPLETED","sponsor":"Baskent University","startDate":"2016-03-01","conditions":"Lateral Epicondylitis","enrollment":54},{"nctId":"NCT04534426","phase":"PHASE4","title":"Topical Arnica and Mucopolysaccharide Polysulfate on Postoperative Pain, Edema and Trismus","status":"COMPLETED","sponsor":"Abant Izzet Baysal University","startDate":"2018-12-01","conditions":"Impacted Third Molar Tooth","enrollment":60},{"nctId":"NCT01910831","phase":"PHASE4","title":"Study to Assess DerMend Moisturizing Bruise Formula in Improving the Appearance of Chronically Aged Forearms and Hands","status":"COMPLETED","sponsor":"The Center for Clinical and Cosmetic Research","startDate":"2013-07","conditions":"Purpura","enrollment":20},{"nctId":"NCT03586232","phase":"NA","title":"Arnica Montana and Bromelain in Rhinoplasty","status":"WITHDRAWN","sponsor":"Boston Medical Center","startDate":"2019-08","conditions":"Wound Healing","enrollment":""},{"nctId":"NCT03569930","phase":"PHASE4","title":"Irritation and Anal Bleeding in Patients Affected by Hemorrhoids.","status":"UNKNOWN","sponsor":"University of Roma La Sapienza","startDate":"2018-05-01","conditions":"Hemorrhoids","enrollment":105},{"nctId":"NCT03520595","phase":"NA","title":"Analgesic Efficacy of Arnica Montana in Comparison With Diclofenac Sodium Following a Periodontal Surgical Procedure","status":"COMPLETED","sponsor":"Tatyasaheb Kore Dental College","startDate":"2016-12-01","conditions":"Crown Lengthening Procedure With Ostectomy","enrollment":60},{"nctId":"NCT03512639","phase":"NA","title":"Arnica Montana and Bellis Perennis for Prevention of Seroma After Mastectomy","status":"COMPLETED","sponsor":"Shaare Zedek Medical Center","startDate":"2016-01-01","conditions":"Seroma","enrollment":55},{"nctId":"NCT01164644","phase":"NA","title":"The Utility of Peri-operative Arnica Montana for Reduction of Ecchymosis in Rhinoplasty Surgery","status":"COMPLETED","sponsor":"University of Wisconsin, Madison","startDate":"2010-06","conditions":"Ecchymosis","enrollment":28},{"nctId":"NCT02207998","phase":"PHASE2","title":"Efficacy of Homoeopathy and Physiotherapy in Chronic Low Back Pain Due to Osteoarthritis","status":"COMPLETED","sponsor":"University of Johannesburg","startDate":"2013-07","conditions":"Osteoarthritis","enrollment":30},{"nctId":"NCT02168335","phase":"PHASE2","title":"The Efficacy of OrasaltsTM in the Treatment of Gingivitis","status":"COMPLETED","sponsor":"University of Johannesburg","startDate":"2014-05","conditions":"Gingivitis","enrollment":40},{"nctId":"NCT01598909","phase":"NA","title":"Efficacy of Arnica D1 Ointment After Upper Blepharoplasty","status":"COMPLETED","sponsor":"Wynand BWH Melenhorst, MD","startDate":"2013-01","conditions":"Blepharoplasty, Upper Eyelid Blepharoplasty","enrollment":136},{"nctId":"NCT01156194","phase":"PHASE3","title":"Homeopathic Remedy for the Third Stage of Delivery","status":"COMPLETED","sponsor":"Shaare Zedek Medical Center","startDate":"2011-01","conditions":"Third Stage of Labor","enrollment":210},{"nctId":"NCT01174511","phase":"PHASE1, PHASE2","title":"Evaluation of A-1 Cool Cream Efficacy for Treatment Atopic Dermatitis","status":"UNKNOWN","sponsor":"Hadassah Medical Organization","startDate":"2011-07","conditions":"ATOPIC DERMATITIS","enrollment":30},{"nctId":"NCT00504010","phase":"PHASE1","title":"The Role of Arnica on Muscle Pain Following Eccentric Exercise","status":"COMPLETED","sponsor":"The University of Texas Health Science Center, Houston","startDate":"2007-08","conditions":"Muscles, Exercise, Arnica","enrollment":55},{"nctId":"NCT00774293","phase":"PHASE4","title":"Homoeopathic Association in Aortic Valve Surgery","status":"COMPLETED","sponsor":"BOIRON","startDate":"2004-09","conditions":"Aortic Valve Replacement","enrollment":92},{"nctId":"NCT00405626","phase":"PHASE1","title":"Double Blind Placebo Controlled Bellis Perenis and Arnica Montana as a Drug for PPH","status":"UNKNOWN","sponsor":"Hadassah Medical Organization","startDate":"2007-04","conditions":"Hemorrhage","enrollment":210},{"nctId":"NCT00222365","phase":"PHASE3","title":"Homeopathy Assessment in Terms of the Consumption of Analgesics After Knee Ligamentoplasty","status":"TERMINATED","sponsor":"University Hospital, Grenoble","startDate":"2003-12","conditions":"Pain","enrollment":165}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":273,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Arnika Krem"],"phase":"marketed","status":"active","brandName":": Arnica montana","genericName":": Arnica montana","companyName":"Abant Izzet Baysal University","companyId":"abant-izzet-baysal-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Arnica montana is a herbal extract that reduces inflammation and promotes tissue healing through multiple phytochemical constituents including sesquiterpenes and flavonoids. Used for Bruising and contusions, Musculoskeletal trauma and swelling, Wound healing promotion.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}