{"id":"arm-e-f-ipv-and-bopv","safety":{"commonSideEffects":[{"rate":null,"effect":"Local injection site reactions (pain, erythema, swelling)"},{"rate":null,"effect":"Fever"},{"rate":null,"effect":"Irritability"},{"rate":null,"effect":"Mild gastrointestinal symptoms"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"f-IPV (fractional-dose inactivated polio vaccine) and bOPV (bivalent oral polio vaccine) work by introducing attenuated or inactivated poliovirus antigens to trigger humoral and mucosal immune responses. f-IPV uses reduced antigen doses of inactivated virus, while bOPV delivers live attenuated virus orally to induce both systemic and intestinal immunity against poliovirus types 1 and 3.","oneSentence":"f-IPV and bOPV are inactivated and bivalent oral polio vaccines that stimulate immune responses against poliovirus types to prevent poliomyelitis infection.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:43:02.137Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Poliomyelitis prevention in infants and children"}]},"trialDetails":[{"nctId":"NCT01813604","phase":"PHASE3","title":"Immunogenicity of Inactivated and Live Polio Vaccines","status":"COMPLETED","sponsor":"Centers for Disease Control and Prevention","startDate":"2012-11","conditions":"Poliomyelitis","enrollment":1206}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Arm E: f-IPV and bOPV","genericName":"Arm E: f-IPV and bOPV","companyName":"Centers for Disease Control and Prevention","companyId":"centers-for-disease-control-and-prevention","modality":"Biologic","firstApprovalDate":"","aiSummary":"f-IPV and bOPV are inactivated and bivalent oral polio vaccines that stimulate immune responses against poliovirus types to prevent poliomyelitis infection. Used for Poliomyelitis prevention in infants and children.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}