{"id":"arm-b-iv-iron-epoietin-zeta-sequence","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypertension"},{"rate":null,"effect":"Thromboembolism"},{"rate":null,"effect":"Injection site reactions"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Fever"}]},"_chembl":{"chemblId":"CHEMBL2108593","moleculeType":"Protein"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Intravenous iron provides essential iron substrate for hemoglobin synthesis, while epoietin zeta (a recombinant erythropoietin) stimulates erythropoiesis by binding to the erythropoietin receptor on bone marrow progenitor cells. Together, they address both iron deficiency and inadequate erythropoietin-mediated red blood cell production.","oneSentence":"This combination therapy replenishes iron stores and stimulates red blood cell production to treat anemia.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:26:24.038Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Chemotherapy-induced anemia"},{"name":"Anemia of chronic disease"}]},"trialDetails":[{"nctId":"NCT02213653","phase":"PHASE4","title":"Randomized Study Evaluating Agents Stimulants Erythropoiesis (ASE) Associated With Ferric Carboxymaltose (Ferinject ®) in Concomitant or Sequential Patients Treated for Cancer and With Anemia Associated With Functional Iron Deficiency","status":"TERMINATED","sponsor":"Centre Francois Baclesse","startDate":"2013-04","conditions":"Solid Cancer Metastatic Disease, Lymphoid Disease","enrollment":24}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"ARM B: IV iron + epoietin zeta sequence","genericName":"ARM B: IV iron + epoietin zeta sequence","companyName":"Centre Francois Baclesse","companyId":"centre-francois-baclesse","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This combination therapy replenishes iron stores and stimulates red blood cell production to treat anemia. Used for Chemotherapy-induced anemia, Anemia of chronic disease.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}