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When this message is sent, blood vessels widen, and blood pressure decreases. This can be helpful for people with conditions like high blood pressure or heart disease.","oneSentence":"Arginate works by increasing the production of nitric oxide, a molecule that helps to relax blood vessels and improve blood flow.","technicalDetail":"Arginate targets inducible nitric oxide synthase (iNOS), an enzyme responsible for producing nitric oxide from the amino acid L-arginine. By increasing the availability of L-arginine, Arginate enhances the production of nitric oxide, leading to vasodilation and improved blood flow."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/4358","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=ARGININE%20GLUTAMATE","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=ARGININE GLUTAMATE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T08:49:19.791371","_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T08:45:08.527602+00:00","fieldsConflicting":0,"overallConfidence":0.95},"biosimilars":[],"competitors":[{"drugName":"glycyrrhizic acid","drugSlug":"glycyrrhizic-acid","fdaApproval":"","relationship":"same-class"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"arginine glutamate","indications":{"approved":[],"offLabel":[],"pipeline":[]},"_fixedFields":["pubmed(139)"],"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"glycyrrhizic-acid","brandName":"glycyrrhizic acid","genericName":"glycyrrhizic acid","approvalYear":"","relationship":"same-class"}],"trialDetails":[{"nctId":"NCT07110532","phase":"PHASE1","title":"pH1N1 Blinded Challenge Study","status":"RECRUITING","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"2025-09-10","conditions":["Influenza"],"enrollment":180,"completionDate":"2026-08-18"},{"nctId":"NCT05498428","phase":"PHASE2","title":"A Study of Amivantamab in Participants With Advanced or Metastatic Solid Tumors Including Epidermal Growth Factor Receptor (EGFR)-Mutated Non-Small Cell Lung Cancer","status":"RECRUITING","sponsor":"Janssen Research & Development, LLC","startDate":"2022-11-11","conditions":["Carcinoma, Non-small-Cell Lung"],"enrollment":520,"completionDate":"2028-08-18"},{"nctId":"NCT00213915","phase":"PHASE4","title":"L-arginine Supplementation and Exercise; 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It is also known by the synonyms Arginine Glutamate.","enrichmentLevel":5,"visitCount":0,"trialStats":{"total":5,"withResults":0},"validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T08:45:08.527602+00:00","fieldsConflicting":0,"overallConfidence":0.95},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}