{"id":"arbutamine","rwe":[{"pmid":"34672012","year":"2022","title":"Target-based drug repurposing against Candida albicans-A computational modeling, docking, and molecular dynamic simulations study.","finding":"","journal":"Journal of cellular biochemistry","studyType":"Clinical Study"},{"pmid":"31052020","year":"2012","title":"Factors Influencing Non-cardiac Side Effects of Dipyridamole When Used for Myocardial Perfusion Stress Testing.","finding":"","journal":"Journal of medical imaging and radiation sciences","studyType":"Clinical Study"},{"pmid":"22285830","year":"2012","title":"A co-module approach for elucidating drug-disease associations and revealing their molecular basis.","finding":"","journal":"Bioinformatics (Oxford, England)","studyType":"Clinical Study"},{"pmid":"17591728","year":"2007","title":"Asymmetric hydrogenation of alpha-primary and secondary amino ketones: efficient asymmetric syntheses of (-)-arbutamine and (-)-denopamine.","finding":"","journal":"Chemistry (Weinheim an der Bergstrasse, Germany)","studyType":"Clinical Study"},{"pmid":"15732229","year":"2004","title":"Sonovue improves endocardial border detection and variability in assessing wall motion score and ejection fraction during stress echocardiography.","finding":"","journal":"Irish journal of medical science","studyType":"Clinical Study"}],"tags":[{"label":"arbutamine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Beta-1 adrenergic receptor","category":"target"},{"label":"ADRB1","category":"gene"},{"label":"C01CA22","category":"atc"},{"label":"Off-Patent","category":"patent"},{"label":"Active","category":"status"},{"label":"Cardiac Function Studies","category":"indication"},{"label":"Approved 1990s","category":"decade"},{"label":"Adrenergic Agents","category":"pharmacology"},{"label":"Adrenergic Agonists","category":"pharmacology"},{"label":"Adrenergic beta-Agonists","category":"pharmacology"},{"label":"Cardiotonic Agents","category":"pharmacology"},{"label":"Cardiovascular Agents","category":"pharmacology"},{"label":"Neurotransmitter Agents","category":"pharmacology"},{"label":"Protective Agents","category":"pharmacology"}],"phase":"marketed","safety":{"commonSideEffects":[],"contraindications":["Acute coronary syndrome","Angle-closure glaucoma","Cardiac pacemaker, device","Chronic heart failure","Hypertensive urgency","Hyperthyroidism","Idiopathic hypertrophic subaortic stenosis","Supraventricular arrhythmia","Tachyarrhythmia"]},"trials":[],"aliases":[],"patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=ARBUTAMINE","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T03:38:48.972183+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T03:38:54.323205+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=ARBUTAMINE","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T03:38:54.532763+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1201251/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T03:38:55.234233+00:00"}},"allNames":"genesa","offLabel":[],"synonyms":["genesa","arbutamine","arbutamine hydrochloride","arbutamine HCl"],"timeline":[{"date":"1997-09-12","type":"positive","source":"DrugCentral","milestone":"FDA approval"}],"aiSummary":"Genesa (Arbutamine) is a small molecule drug that targets the beta-1 adrenergic receptor. 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